Forskning ved Københavns Universitet - Københavns Universitet

Forside

Markers of HPA-axis activity and nucleic acid damage from oxidation after electroconvulsive stimulations in rats

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Markers of HPA-axis activity and nucleic acid damage from oxidation after electroconvulsive stimulations in rats. / Jørgensen, Anders; Breitenstein, Katrine; Kalliokoski, Otto; Weimann, Allan; Henriksen, Trine; Poulsen, Henrik Enghusen; Jørgensen, Martin Balslev; Wörtwein, Gitta.

I: Acta Neuropsychiatrica, Bind 31, Nr. 6, 2019, s. 287-293.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Jørgensen, A, Breitenstein, K, Kalliokoski, O, Weimann, A, Henriksen, T, Poulsen, HE, Jørgensen, MB & Wörtwein, G 2019, 'Markers of HPA-axis activity and nucleic acid damage from oxidation after electroconvulsive stimulations in rats', Acta Neuropsychiatrica, bind 31, nr. 6, s. 287-293. https://doi.org/10.1017/neu.2019.7

APA

Jørgensen, A., Breitenstein, K., Kalliokoski, O., Weimann, A., Henriksen, T., Poulsen, H. E., Jørgensen, M. B., & Wörtwein, G. (2019). Markers of HPA-axis activity and nucleic acid damage from oxidation after electroconvulsive stimulations in rats. Acta Neuropsychiatrica, 31(6), 287-293. https://doi.org/10.1017/neu.2019.7

Vancouver

Jørgensen A, Breitenstein K, Kalliokoski O, Weimann A, Henriksen T, Poulsen HE o.a. Markers of HPA-axis activity and nucleic acid damage from oxidation after electroconvulsive stimulations in rats. Acta Neuropsychiatrica. 2019;31(6):287-293. https://doi.org/10.1017/neu.2019.7

Author

Jørgensen, Anders ; Breitenstein, Katrine ; Kalliokoski, Otto ; Weimann, Allan ; Henriksen, Trine ; Poulsen, Henrik Enghusen ; Jørgensen, Martin Balslev ; Wörtwein, Gitta. / Markers of HPA-axis activity and nucleic acid damage from oxidation after electroconvulsive stimulations in rats. I: Acta Neuropsychiatrica. 2019 ; Bind 31, Nr. 6. s. 287-293.

Bibtex

@article{fd9718242d504f99bccddc44524f49c3,
title = "Markers of HPA-axis activity and nucleic acid damage from oxidation after electroconvulsive stimulations in rats",
abstract = "Objective:Oxidative stress has been suggested to increase after electroconvulsive therapy (ECT); a treatment which continues to be the most effective for severe depression. Oxidative stress could potentially be mechanistically involved in both the therapeutic effects and side-effects of ECT.Methods:We measured sensitive markers of systemic and CNS oxidative stress on DNA and RNA (urinary 8-oxodG/8-oxoGuo, cerebrospinal fluid 8-oxoGuo, and brain oxoguanine glycosylase mRNA expression) in male rats subjected to electroconvulsive stimulations (ECS); an animal model of ECT. Due to previous observations that link hypothalamic-pituitary-adrenal (HPA)-axis activity and age to DNA/RNA damage from oxidation, groups of young and middle-aged male animals were included, and markers of HPA-axis activity were measured.Results:ECS induced weight loss, corticosterone increases (only in middle-aged animals), and decreased cerebral glucocorticoid receptor mRNA expression, while largely leaving the markers of systemic and CNS DNA/RNA damage from oxidation unaltered.Conclusion:These results suggest that ECS is not associated with any lasting effects on oxidative stress on nucleic acids neither in young or middle-aged rats.",
keywords = "DNA repair, Electroconvulsive stimulations, HPA-axis, nucleic acids, oxidative stress",
author = "Anders J{\o}rgensen and Katrine Breitenstein and Otto Kalliokoski and Allan Weimann and Trine Henriksen and Poulsen, {Henrik Enghusen} and J{\o}rgensen, {Martin Balslev} and Gitta W{\"o}rtwein",
year = "2019",
doi = "10.1017/neu.2019.7",
language = "English",
volume = "31",
pages = "287--293",
journal = "Acta Neuropsychiatrica",
issn = "0924-2708",
publisher = "Cambridge University Press",
number = "6",

}

RIS

TY - JOUR

T1 - Markers of HPA-axis activity and nucleic acid damage from oxidation after electroconvulsive stimulations in rats

AU - Jørgensen, Anders

AU - Breitenstein, Katrine

AU - Kalliokoski, Otto

AU - Weimann, Allan

AU - Henriksen, Trine

AU - Poulsen, Henrik Enghusen

AU - Jørgensen, Martin Balslev

AU - Wörtwein, Gitta

PY - 2019

Y1 - 2019

N2 - Objective:Oxidative stress has been suggested to increase after electroconvulsive therapy (ECT); a treatment which continues to be the most effective for severe depression. Oxidative stress could potentially be mechanistically involved in both the therapeutic effects and side-effects of ECT.Methods:We measured sensitive markers of systemic and CNS oxidative stress on DNA and RNA (urinary 8-oxodG/8-oxoGuo, cerebrospinal fluid 8-oxoGuo, and brain oxoguanine glycosylase mRNA expression) in male rats subjected to electroconvulsive stimulations (ECS); an animal model of ECT. Due to previous observations that link hypothalamic-pituitary-adrenal (HPA)-axis activity and age to DNA/RNA damage from oxidation, groups of young and middle-aged male animals were included, and markers of HPA-axis activity were measured.Results:ECS induced weight loss, corticosterone increases (only in middle-aged animals), and decreased cerebral glucocorticoid receptor mRNA expression, while largely leaving the markers of systemic and CNS DNA/RNA damage from oxidation unaltered.Conclusion:These results suggest that ECS is not associated with any lasting effects on oxidative stress on nucleic acids neither in young or middle-aged rats.

AB - Objective:Oxidative stress has been suggested to increase after electroconvulsive therapy (ECT); a treatment which continues to be the most effective for severe depression. Oxidative stress could potentially be mechanistically involved in both the therapeutic effects and side-effects of ECT.Methods:We measured sensitive markers of systemic and CNS oxidative stress on DNA and RNA (urinary 8-oxodG/8-oxoGuo, cerebrospinal fluid 8-oxoGuo, and brain oxoguanine glycosylase mRNA expression) in male rats subjected to electroconvulsive stimulations (ECS); an animal model of ECT. Due to previous observations that link hypothalamic-pituitary-adrenal (HPA)-axis activity and age to DNA/RNA damage from oxidation, groups of young and middle-aged male animals were included, and markers of HPA-axis activity were measured.Results:ECS induced weight loss, corticosterone increases (only in middle-aged animals), and decreased cerebral glucocorticoid receptor mRNA expression, while largely leaving the markers of systemic and CNS DNA/RNA damage from oxidation unaltered.Conclusion:These results suggest that ECS is not associated with any lasting effects on oxidative stress on nucleic acids neither in young or middle-aged rats.

KW - DNA repair

KW - Electroconvulsive stimulations

KW - HPA-axis

KW - nucleic acids

KW - oxidative stress

U2 - 10.1017/neu.2019.7

DO - 10.1017/neu.2019.7

M3 - Journal article

C2 - 30854991

AN - SCOPUS:85063165332

VL - 31

SP - 287

EP - 293

JO - Acta Neuropsychiatrica

JF - Acta Neuropsychiatrica

SN - 0924-2708

IS - 6

ER -

ID: 223975506