Forskning ved Københavns Universitet - Københavns Universitet

Forside

Maternal use of acetaminophen, ibuprofen, and acetylsalicylic acid during pregnancy and risk of cryptorchidism

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Morten Søndergaard Jensen
  • Cristina Rebordosa
  • Ane Marie Thulstrup
  • Gunnar Toft
  • Henrik Toft Sørensen
  • Bonde, Jens Peter
  • Tine Brink Henriksen
  • Jørn Olsen
Cyclooxygenase (COX) inhibitors-acetaminophen, ibuprofen and acetylsalicylic acid-have endocrine-disruptive properties in the rainbow trout. In humans, aspirin blocks the androgen response to human chorionic gonadotropin (hCG), and, because hCG-stimulated androgen production in utero is crucial for normal testicular descent, exposure to COX inhibitors at vulnerable times during gestation may impair testicular descent. We examined whether prenatal exposure to acetaminophen, ibuprofen, and acetylsalicylic acid was associated with increased occurrence of cryptorchidism.
OriginalsprogEngelsk
TidsskriftEpidemiology
Vol/bind21
Udgave nummer6
Sider (fra-til)779-85
Antal sider7
ISSN1044-3983
DOI
StatusUdgivet - 1 nov. 2010

ID: 40220557