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Mechanism and Scope of Base-Controlled Catalyst-Free N-Arylation of Amines with Unactivated Fluorobenzenes

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

A general method for transition metal-free N-arylation of amines has been developed. Mechanistic studies have revealed that the ability of the base to facilitate the desired amination without promoting unwanted side reactions is the guiding factor. By employing lithium bis(trimethylsilyl)amide as a base the resultant deprotonated amines readily react with a range of unactivated fluorobenzene derivatives. This new arylation method is utilized for the simple two-step synthesis of the antidepressant Vortioxetine
OriginalsprogEngelsk
TidsskriftChemistry: A European Journal
Vol/bind23
Udgave nummer4
Sider (fra-til)846-851
Antal sider6
ISSN0947-6539
DOI
StatusUdgivet - 2017

ID: 176369254