Forskning ved Københavns Universitet - Københavns Universitet

Forside

Mediation analysis for logistic regression with interactions: Application of a surrogate marker in ophthalmology

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Dokumenter

Mediation analysis is often based on fitting two models, one including and another excluding a potential mediator, and subsequently quantify the mediated effects by combining parameter estimates from these two models. Standard errors of such derived parameters may be approximated using the delta method. For a study evaluating a treatment effect on visual acuity, a binary outcome, we demonstrate how mediation analysis may conveniently be carried out by means of marginally fitted logistic regression models in combination with the delta method. Several metrics of mediation are estimated and results are compared to findings using existing methods.

OriginalsprogEngelsk
Artikelnummere0192857
TidsskriftP L o S One
Vol/bind13
Udgave nummer2
Antal sider7
ISSN1932-6203
DOI
StatusUdgivet - 2018

Bibliografisk note

CURIS 2018 NEXS 069

Antal downloads er baseret på statistik fra Google Scholar og www.ku.dk


Ingen data tilgængelig

ID: 189867671