Forskning ved Københavns Universitet - Københavns Universitet


Medication overuse headache in Europe and Latin America: general demographic and clinical characteristics, referral pathways and national distribution of painkillers in a descriptive, multinational, multicenter study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Ninett Louise Find
  • Rossana Terlizzi
  • Signe Bruun Munksgaard
  • Bendtsen, Lars
  • Cristina Tassorelli
  • Giuseppe Nappi
  • Zaza Katsarava
  • Miguel Ja Láinez
  • Maria Teresa Goicochea
  • Beatriz Shand
  • Ricardo Fadic
  • Santiago Spadafora
  • Marco Pagani
  • Jensen, Rigmor Højland

Background: Medication overuse headache (MOH) is a very disabling and costly disorder due to indirect costs, medication and healthcare utilization. The aim of the study was to describe general demographic and clinical characteristics of MOH, along with the national referral pathways and national painkillers distribution in several European and Latin American (LA) Countries. Methods: This descriptive cross-sectional observational study included 669 patients with MOH referred to headache-centers in Europe and LA as a part of the COMOESTAS project. Information about acute medication and healthcare utilization were collected by extensive questionnaires, supplemented with structured patient interviews. Results: Triptans were overused by 31 % European patients and by 6 % in LA (p < 0.001), whereas ergotamines were overused by 4 % in Europe and 72 % in LA (p < 0.001). Simple analgesics were overused by 54 % in Europe and by 33 % in LA (p < 0.001), while combination-analgesics were more equally overused (24 % in Europe and 29 % in LA). More European patients (57 %) compared with LA patients (27 %) visited general practitioners (p < 0.001), and 83 % of European patients compared to 38 % in LA consulted headache specialists (p < 0.001). A total of 20 % in Europe and 30 % in LA visited emergency rooms (p = 0.007). Conclusion: There are marked variations between LA and Europe in healthcare pathways and in acute medication overuse regarding patients with MOH. This should be considered when planning prevention campaigns against MOH.

TidsskriftJournal of Headache and Pain
Udgave nummer1
StatusUdgivet - 2016

Antal downloads er baseret på statistik fra Google Scholar og

Ingen data tilgængelig

ID: 179171514