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Memory Correlates of Alzheimer's Disease Cerebrospinal Fluid Markers: A Longitudinal Cohort Study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Babette L R Reijs
  • Inez H G B Ramakers
  • Sebastian Köhler
  • Charlotte E Teunissen
  • Marleen Koel-Simmelink
  • Pradeep J Nathan
  • Magda Tsolaki
  • Lars-Olof Wahlund
  • Waldemar, Gunhild
  • Lucrezia Hausner
  • Rik Vandenberghe
  • Peter Johannsen
  • Andrew Blackwell
  • Hugo Vanderstichele
  • Frans Verhey
  • Pieter Jelle Visser

BACKGROUND: Performance on episodic, semantic, and working memory tests is impaired in Alzheimer's disease (AD)-type dementia, but it is unclear which type of memory test is most strongly associated with early AD biomarkers in cerebrospinal fluid (CSF), and most useful for monitoring disease progression.

OBJECTIVE: To examine the association between amyloid-β 1-42 (Aβ42) and tau in CSF with performance on different memory domains at baseline, and how these CSF markers are related with memory decline.

METHODS: We included 263 individuals with normal cognition, mild cognitive impairment, AD-type dementia, and non-AD dementia from the European EDAR study. Assessment included CSF Aβ42 and t-tau analyses with INNO-BIA AlzBio3 Luminex assay, the CERAD wordlist learning and delayed recall, animal fluency test, and the CANTAB Paired Associates Learning (PAL) and Spatial Working Memory tasks. Follow-up assessments were performed within 3 years after baseline.

RESULTS: At baseline, decreased CSF Aβ42 correlated most strongly with the PAL total errors adjusted and the wordlist delayed recall and increased CSF t-tau with the wordlist delayed recall. Over time, decreased CSF Aβ42 was associated with decline on the wordlist learning, whereas increased CSF t-tau were associated with decline in scores on the wordlist learning, wordlist delayed recall, and animal fluency. Associations were independent of baseline diagnosis.

CONCLUSION: Tests assessing episodic verbal and visuospatial memory are most useful for detection of AD pathology. Tests for episodic verbal memory and semantic memory are most useful for tracking memory decline.

OriginalsprogEngelsk
TidsskriftJournal of Alzheimer's Disease
Vol/bind60
Udgave nummer3
Sider (fra-til)1119-1128
Antal sider10
ISSN1387-2877
DOI
StatusUdgivet - 2017

ID: 186083863