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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. / Heid, Iris M; Jackson, Anne U; Randall, Joshua C; Winkler, Thomas W; Qi, Lu; Steinthorsdottir, Valgerdur; Thorleifsson, Gudmar; Zillikens, M Carola; Speliotes, Elizabeth K; Mägi, Reedik; Workalemahu, Tsegaselassie; White, Charles C; Bouatia-Naji, Nabila; Harris, Tamara B; Berndt, Sonja I; Ingelsson, Erik; Willer, Cristen J; Weedon, Michael N; Luan, Jian'an; Vedantam, Sailaja; Esko, Tõnu; Oskari Kilpeläinen, Tuomas; Kutalik, Zoltán; Li, Shengxu; Monda, Keri L; Dixon, Anna L; Holmes, Christopher C; Kaplan, Lee M; Liang, Liming; Min, Josine L; Moffatt, Miriam F; Molony, Cliona; Nicholson, George; Schadt, Eric E; Zondervan, Krina T; Feitosa, Mary F; Ferreira, Teresa; Allen, Hana Lango; Weyant, Robert J; Wheeler, Eleanor; Wood, Andrew R; Estrada, Karol; Goddard, Michael E; Lettre, Guillaume; Mangino, Massimo; Gjesing, Anette P; Witte, Daniel R; Hansen, Torben; Jørgensen, Torben; Pedersen, Oluf; MAGIC.

I: Nature Genetics, Bind 42, Nr. 11, 01.11.2010, s. 949-60.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Heid, IM, Jackson, AU, Randall, JC, Winkler, TW, Qi, L, Steinthorsdottir, V, Thorleifsson, G, Zillikens, MC, Speliotes, EK, Mägi, R, Workalemahu, T, White, CC, Bouatia-Naji, N, Harris, TB, Berndt, SI, Ingelsson, E, Willer, CJ, Weedon, MN, Luan, J, Vedantam, S, Esko, T, Oskari Kilpeläinen, T, Kutalik, Z, Li, S, Monda, KL, Dixon, AL, Holmes, CC, Kaplan, LM, Liang, L, Min, JL, Moffatt, MF, Molony, C, Nicholson, G, Schadt, EE, Zondervan, KT, Feitosa, MF, Ferreira, T, Allen, HL, Weyant, RJ, Wheeler, E, Wood, AR, Estrada, K, Goddard, ME, Lettre, G, Mangino, M, Gjesing, AP, Witte, DR, Hansen, T, Jørgensen, T, Pedersen, O & MAGIC 2010, 'Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution', Nature Genetics, bind 42, nr. 11, s. 949-60. https://doi.org/10.1038/ng.685

APA

Heid, I. M., Jackson, A. U., Randall, J. C., Winkler, T. W., Qi, L., Steinthorsdottir, V., ... MAGIC (2010). Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nature Genetics, 42(11), 949-60. https://doi.org/10.1038/ng.685

Vancouver

Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V o.a. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nature Genetics. 2010 nov 1;42(11):949-60. https://doi.org/10.1038/ng.685

Author

Heid, Iris M ; Jackson, Anne U ; Randall, Joshua C ; Winkler, Thomas W ; Qi, Lu ; Steinthorsdottir, Valgerdur ; Thorleifsson, Gudmar ; Zillikens, M Carola ; Speliotes, Elizabeth K ; Mägi, Reedik ; Workalemahu, Tsegaselassie ; White, Charles C ; Bouatia-Naji, Nabila ; Harris, Tamara B ; Berndt, Sonja I ; Ingelsson, Erik ; Willer, Cristen J ; Weedon, Michael N ; Luan, Jian'an ; Vedantam, Sailaja ; Esko, Tõnu ; Oskari Kilpeläinen, Tuomas ; Kutalik, Zoltán ; Li, Shengxu ; Monda, Keri L ; Dixon, Anna L ; Holmes, Christopher C ; Kaplan, Lee M ; Liang, Liming ; Min, Josine L ; Moffatt, Miriam F ; Molony, Cliona ; Nicholson, George ; Schadt, Eric E ; Zondervan, Krina T ; Feitosa, Mary F ; Ferreira, Teresa ; Allen, Hana Lango ; Weyant, Robert J ; Wheeler, Eleanor ; Wood, Andrew R ; Estrada, Karol ; Goddard, Michael E ; Lettre, Guillaume ; Mangino, Massimo ; Gjesing, Anette P ; Witte, Daniel R ; Hansen, Torben ; Jørgensen, Torben ; Pedersen, Oluf ; MAGIC. / Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. I: Nature Genetics. 2010 ; Bind 42, Nr. 11. s. 949-60.

Bibtex

@article{f80fd0b43dd3401bb287e976597934ce,
title = "Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution",
abstract = "Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10¿¿ to P = 1.8 × 10¿4°) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10¿³ to P = 1.2 × 10¿¹³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.",
keywords = "Adipose Tissue, Age Factors, Chromosome Mapping, Female, Genome, Human, Genome-Wide Association Study, Humans, Male, Meta-Analysis as Topic, Polymorphism, Single Nucleotide, Sex Characteristics, Waist-Hip Ratio",
author = "Heid, {Iris M} and Jackson, {Anne U} and Randall, {Joshua C} and Winkler, {Thomas W} and Lu Qi and Valgerdur Steinthorsdottir and Gudmar Thorleifsson and Zillikens, {M Carola} and Speliotes, {Elizabeth K} and Reedik M{\"a}gi and Tsegaselassie Workalemahu and White, {Charles C} and Nabila Bouatia-Naji and Harris, {Tamara B} and Berndt, {Sonja I} and Erik Ingelsson and Willer, {Cristen J} and Weedon, {Michael N} and Jian'an Luan and Sailaja Vedantam and T{\~o}nu Esko and {Oskari Kilpel{\"a}inen}, Tuomas and Zolt{\'a}n Kutalik and Shengxu Li and Monda, {Keri L} and Dixon, {Anna L} and Holmes, {Christopher C} and Kaplan, {Lee M} and Liming Liang and Min, {Josine L} and Moffatt, {Miriam F} and Cliona Molony and George Nicholson and Schadt, {Eric E} and Zondervan, {Krina T} and Feitosa, {Mary F} and Teresa Ferreira and Allen, {Hana Lango} and Weyant, {Robert J} and Eleanor Wheeler and Wood, {Andrew R} and Karol Estrada and Goddard, {Michael E} and Guillaume Lettre and Massimo Mangino and Gjesing, {Anette P} and Witte, {Daniel R} and Torben Hansen and Torben J{\o}rgensen and Oluf Pedersen and MAGIC",
year = "2010",
month = "11",
day = "1",
doi = "10.1038/ng.685",
language = "English",
volume = "42",
pages = "949--60",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "11",

}

RIS

TY - JOUR

T1 - Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

AU - Heid, Iris M

AU - Jackson, Anne U

AU - Randall, Joshua C

AU - Winkler, Thomas W

AU - Qi, Lu

AU - Steinthorsdottir, Valgerdur

AU - Thorleifsson, Gudmar

AU - Zillikens, M Carola

AU - Speliotes, Elizabeth K

AU - Mägi, Reedik

AU - Workalemahu, Tsegaselassie

AU - White, Charles C

AU - Bouatia-Naji, Nabila

AU - Harris, Tamara B

AU - Berndt, Sonja I

AU - Ingelsson, Erik

AU - Willer, Cristen J

AU - Weedon, Michael N

AU - Luan, Jian'an

AU - Vedantam, Sailaja

AU - Esko, Tõnu

AU - Oskari Kilpeläinen, Tuomas

AU - Kutalik, Zoltán

AU - Li, Shengxu

AU - Monda, Keri L

AU - Dixon, Anna L

AU - Holmes, Christopher C

AU - Kaplan, Lee M

AU - Liang, Liming

AU - Min, Josine L

AU - Moffatt, Miriam F

AU - Molony, Cliona

AU - Nicholson, George

AU - Schadt, Eric E

AU - Zondervan, Krina T

AU - Feitosa, Mary F

AU - Ferreira, Teresa

AU - Allen, Hana Lango

AU - Weyant, Robert J

AU - Wheeler, Eleanor

AU - Wood, Andrew R

AU - Estrada, Karol

AU - Goddard, Michael E

AU - Lettre, Guillaume

AU - Mangino, Massimo

AU - Gjesing, Anette P

AU - Witte, Daniel R

AU - Hansen, Torben

AU - Jørgensen, Torben

AU - Pedersen, Oluf

AU - MAGIC

PY - 2010/11/1

Y1 - 2010/11/1

N2 - Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10¿¿ to P = 1.8 × 10¿4°) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10¿³ to P = 1.2 × 10¿¹³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.

AB - Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10¿¿ to P = 1.8 × 10¿4°) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10¿³ to P = 1.2 × 10¿¹³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.

KW - Adipose Tissue

KW - Age Factors

KW - Chromosome Mapping

KW - Female

KW - Genome, Human

KW - Genome-Wide Association Study

KW - Humans

KW - Male

KW - Meta-Analysis as Topic

KW - Polymorphism, Single Nucleotide

KW - Sex Characteristics

KW - Waist-Hip Ratio

U2 - 10.1038/ng.685

DO - 10.1038/ng.685

M3 - Journal article

C2 - 20935629

VL - 42

SP - 949

EP - 960

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 11

ER -

ID: 33497691