Forskning ved Københavns Universitet - Københavns Universitet

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Mitochondria in the signaling pathways that control longevity and health span

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

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Genetic and pharmacological intervention studies have identified evolutionarily conserved and functionally interconnected networks of cellular energy homeostasis, nutrient-sensing, and genome damage response signaling pathways, as prominent regulators of longevity and health span in various species. Mitochondria are the primary sites of ATP production and key players in several other important cellular processes. Mitochondrial dysfunction diminishes tissue and organ functional performance and is a commonly considered feature of the aging process. Here we review the evidence that through reciprocal and multilevel functional interactions, mitochondria are implicated in the lifespan modulation function of these pathways, which altogether constitute a highly dynamic and complex system that controls the aging process. An important characteristic of these pathways is their extensive crosstalk and apparent malleability to modification by non-invasive pharmacological, dietary, and lifestyle interventions, with promising effects on lifespan and health span in animal models and potentially also in humans.

OriginalsprogEngelsk
Artikelnummer100940
TidsskriftAgeing Research Reviews
Vol/bind54
ISSN1568-1637
DOI
StatusUdgivet - 2019

Bibliografisk note

Copyright © 2019. Published by Elsevier B.V.

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