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MitophAging: Mitophagy in Aging and Disease

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

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Maintaining mitochondrial health is emerging as a keystone in aging and associated diseases. The selective degradation of mitochondria by mitophagy is of particular importance in keeping a pristine mitochondrial pool. Indeed, inherited monogenic diseases with defects in mitophagy display complex multisystem pathologies but particularly progressive neurodegeneration. Fortunately, therapies are being developed that target mitophagy allowing new hope for treatments for previously incurable diseases. Herein, we describe mitophagy and associated diseases, coin the term mitophaging and describe new small molecule interventions that target different steps in the mitophagic pathway. Consequently, several age-associated diseases may be treated by targeting mitophagy.

OriginalsprogEngelsk
Artikelnummer239
TidsskriftFrontiers in Cell and Developmental Biology
Vol/bind8
Antal sider16
ISSN2296-634X
DOI
StatusUdgivet - 2020

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