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Mitral Regurgitation Severity and Left Ventricular Systolic Dimension Predict Survival in Young Cavalier King Charles Spaniels

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Mitral Regurgitation Severity and Left Ventricular Systolic Dimension Predict Survival in Young Cavalier King Charles Spaniels. / Reimann, M. J.; Moller, J. E.; Haggstrom, J.; Martinussen, T.; Zatrazemi, S. S. C.; Svanholm, L.; Nielsen, L. B. M.; Pedersen, H. D.; Olsen, L. H.

I: Journal of Veterinary Internal Medicine, Bind 31, Nr. 4, 2017, s. 1008-1016.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Reimann, MJ, Moller, JE, Haggstrom, J, Martinussen, T, Zatrazemi, SSC, Svanholm, L, Nielsen, LBM, Pedersen, HD & Olsen, LH 2017, 'Mitral Regurgitation Severity and Left Ventricular Systolic Dimension Predict Survival in Young Cavalier King Charles Spaniels', Journal of Veterinary Internal Medicine, bind 31, nr. 4, s. 1008-1016. https://doi.org/10.1111/jvim.14759

APA

Reimann, M. J., Moller, J. E., Haggstrom, J., Martinussen, T., Zatrazemi, S. S. C., Svanholm, L., Nielsen, L. B. M., Pedersen, H. D., & Olsen, L. H. (2017). Mitral Regurgitation Severity and Left Ventricular Systolic Dimension Predict Survival in Young Cavalier King Charles Spaniels. Journal of Veterinary Internal Medicine, 31(4), 1008-1016. https://doi.org/10.1111/jvim.14759

Vancouver

Reimann MJ, Moller JE, Haggstrom J, Martinussen T, Zatrazemi SSC, Svanholm L o.a. Mitral Regurgitation Severity and Left Ventricular Systolic Dimension Predict Survival in Young Cavalier King Charles Spaniels. Journal of Veterinary Internal Medicine. 2017;31(4):1008-1016. https://doi.org/10.1111/jvim.14759

Author

Reimann, M. J. ; Moller, J. E. ; Haggstrom, J. ; Martinussen, T. ; Zatrazemi, S. S. C. ; Svanholm, L. ; Nielsen, L. B. M. ; Pedersen, H. D. ; Olsen, L. H. / Mitral Regurgitation Severity and Left Ventricular Systolic Dimension Predict Survival in Young Cavalier King Charles Spaniels. I: Journal of Veterinary Internal Medicine. 2017 ; Bind 31, Nr. 4. s. 1008-1016.

Bibtex

@article{e0ed2b2d3d5746f9a42a7041cb7e7fb5,
title = "Mitral Regurgitation Severity and Left Ventricular Systolic Dimension Predict Survival in Young Cavalier King Charles Spaniels",
abstract = "Background Development and progression of myxomatous mitral valve disease (MMVD) in dogs are difficult to predict. Identification at a young age of dogs at high risk of adverse outcome in the future is desirable. Hypothesis/Objectives To study the predictive value of selected clinical and echocardiographic characteristics associated with MMVD obtained at a young age for prediction of long-term cardiac and all-cause mortality in Cavalier King Charles Spaniels (CKCS). Animals 1125 privately owned CKCS. Methods A retrospective study including CKCS examined at the age of 1–3 years. Long-term outcome was assessed by telephone interview with owners. The value of variables for predicting mortality was investigated by Cox proportional hazard and Kaplan-Meier analyses. Results Presence of moderate to severe mitral regurgitation (MR) (hazard ratio (HR) = 3.03, 95% confidence interval (95% CI) = 1.48–6.23, P = 0.0025) even intermittent moderate to severe MR (HR = 2.23, 95% CI = 1.48–6.23, P = 0.039) on color flow Doppler echocardiography was significantly associated with increased hazard of cardiac death. An interaction between MR and sex was significant for all-cause mortality (P = 0.035), showing that males with moderate to severe MR had a higher all-cause mortality compared to males with no MR (HR = 2.38, 95% CI = 1.27–4.49, P = 0.0071), whereas no difference was found between female MR groups. The risk of cardiac (HR = 1.37, 95% CI = 1.14–1.63, P < 0.001) and all-cause (HR = 1.13, 95% CI = 1.02–1.24, P = 0.016) mortality increased with increasing left ventricular end-systolic internal dimension normalized for body weight (LVIDSN). Conclusions and clinical importance Moderate to severe MR, even if intermittent, and increased LVIDSN in dogs <3 years of age were associated with cardiac death later in life in CKCS.",
keywords = "Dog, Heart failure, Myxomatous Mitral Valve Disease, Risk factor",
author = "Reimann, {M. J.} and Moller, {J. E.} and J. Haggstrom and T. Martinussen and Zatrazemi, {S. S. C.} and L. Svanholm and Nielsen, {L. B. M.} and Pedersen, {H. D.} and Olsen, {L. H.}",
year = "2017",
doi = "10.1111/jvim.14759",
language = "English",
volume = "31",
pages = "1008--1016",
journal = "Journal of Veterinary Internal Medicine",
issn = "0891-6640",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Mitral Regurgitation Severity and Left Ventricular Systolic Dimension Predict Survival in Young Cavalier King Charles Spaniels

AU - Reimann, M. J.

AU - Moller, J. E.

AU - Haggstrom, J.

AU - Martinussen, T.

AU - Zatrazemi, S. S. C.

AU - Svanholm, L.

AU - Nielsen, L. B. M.

AU - Pedersen, H. D.

AU - Olsen, L. H.

PY - 2017

Y1 - 2017

N2 - Background Development and progression of myxomatous mitral valve disease (MMVD) in dogs are difficult to predict. Identification at a young age of dogs at high risk of adverse outcome in the future is desirable. Hypothesis/Objectives To study the predictive value of selected clinical and echocardiographic characteristics associated with MMVD obtained at a young age for prediction of long-term cardiac and all-cause mortality in Cavalier King Charles Spaniels (CKCS). Animals 1125 privately owned CKCS. Methods A retrospective study including CKCS examined at the age of 1–3 years. Long-term outcome was assessed by telephone interview with owners. The value of variables for predicting mortality was investigated by Cox proportional hazard and Kaplan-Meier analyses. Results Presence of moderate to severe mitral regurgitation (MR) (hazard ratio (HR) = 3.03, 95% confidence interval (95% CI) = 1.48–6.23, P = 0.0025) even intermittent moderate to severe MR (HR = 2.23, 95% CI = 1.48–6.23, P = 0.039) on color flow Doppler echocardiography was significantly associated with increased hazard of cardiac death. An interaction between MR and sex was significant for all-cause mortality (P = 0.035), showing that males with moderate to severe MR had a higher all-cause mortality compared to males with no MR (HR = 2.38, 95% CI = 1.27–4.49, P = 0.0071), whereas no difference was found between female MR groups. The risk of cardiac (HR = 1.37, 95% CI = 1.14–1.63, P < 0.001) and all-cause (HR = 1.13, 95% CI = 1.02–1.24, P = 0.016) mortality increased with increasing left ventricular end-systolic internal dimension normalized for body weight (LVIDSN). Conclusions and clinical importance Moderate to severe MR, even if intermittent, and increased LVIDSN in dogs <3 years of age were associated with cardiac death later in life in CKCS.

AB - Background Development and progression of myxomatous mitral valve disease (MMVD) in dogs are difficult to predict. Identification at a young age of dogs at high risk of adverse outcome in the future is desirable. Hypothesis/Objectives To study the predictive value of selected clinical and echocardiographic characteristics associated with MMVD obtained at a young age for prediction of long-term cardiac and all-cause mortality in Cavalier King Charles Spaniels (CKCS). Animals 1125 privately owned CKCS. Methods A retrospective study including CKCS examined at the age of 1–3 years. Long-term outcome was assessed by telephone interview with owners. The value of variables for predicting mortality was investigated by Cox proportional hazard and Kaplan-Meier analyses. Results Presence of moderate to severe mitral regurgitation (MR) (hazard ratio (HR) = 3.03, 95% confidence interval (95% CI) = 1.48–6.23, P = 0.0025) even intermittent moderate to severe MR (HR = 2.23, 95% CI = 1.48–6.23, P = 0.039) on color flow Doppler echocardiography was significantly associated with increased hazard of cardiac death. An interaction between MR and sex was significant for all-cause mortality (P = 0.035), showing that males with moderate to severe MR had a higher all-cause mortality compared to males with no MR (HR = 2.38, 95% CI = 1.27–4.49, P = 0.0071), whereas no difference was found between female MR groups. The risk of cardiac (HR = 1.37, 95% CI = 1.14–1.63, P < 0.001) and all-cause (HR = 1.13, 95% CI = 1.02–1.24, P = 0.016) mortality increased with increasing left ventricular end-systolic internal dimension normalized for body weight (LVIDSN). Conclusions and clinical importance Moderate to severe MR, even if intermittent, and increased LVIDSN in dogs <3 years of age were associated with cardiac death later in life in CKCS.

KW - Dog

KW - Heart failure

KW - Myxomatous Mitral Valve Disease

KW - Risk factor

U2 - 10.1111/jvim.14759

DO - 10.1111/jvim.14759

M3 - Journal article

C2 - 28573754

VL - 31

SP - 1008

EP - 1016

JO - Journal of Veterinary Internal Medicine

JF - Journal of Veterinary Internal Medicine

SN - 0891-6640

IS - 4

ER -

ID: 182581850