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MRI-defined subcortical ischemic vascular disease: baseline clinical and neuropsychological findings. The LADIS Study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

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MRI-defined subcortical ischemic vascular disease: baseline clinical and neuropsychological findings. The LADIS Study. / Jokinen, Hanna; Kalska, Hely; Ylikoski, Raija; Madureira, Sofia; Verdelho, Ana; Gouw, Alida; Scheltens, Philip; Barkhof, Frederik; Visser, Marieke C; Fazekas, Franz; Schmidt, Reinhold; O'Brien, John; Hennerici, Michael; Baezner, Hansjorg; Waldemar, Gunhild; Wallin, Anders; Chabriat, Hugues; Pantoni, Leonardo; Inzitari, Domenico; Erkinjuntti, Timo; LADIS group.

I: Cerebrovascular Diseases, Bind 27, Nr. 4, 2009, s. 336-44.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Jokinen, H, Kalska, H, Ylikoski, R, Madureira, S, Verdelho, A, Gouw, A, Scheltens, P, Barkhof, F, Visser, MC, Fazekas, F, Schmidt, R, O'Brien, J, Hennerici, M, Baezner, H, Waldemar, G, Wallin, A, Chabriat, H, Pantoni, L, Inzitari, D, Erkinjuntti, T & LADIS group 2009, 'MRI-defined subcortical ischemic vascular disease: baseline clinical and neuropsychological findings. The LADIS Study', Cerebrovascular Diseases, bind 27, nr. 4, s. 336-44. https://doi.org/10.1159/000202010

APA

Jokinen, H., Kalska, H., Ylikoski, R., Madureira, S., Verdelho, A., Gouw, A., Scheltens, P., Barkhof, F., Visser, M. C., Fazekas, F., Schmidt, R., O'Brien, J., Hennerici, M., Baezner, H., Waldemar, G., Wallin, A., Chabriat, H., Pantoni, L., Inzitari, D., ... LADIS group (2009). MRI-defined subcortical ischemic vascular disease: baseline clinical and neuropsychological findings. The LADIS Study. Cerebrovascular Diseases, 27(4), 336-44. https://doi.org/10.1159/000202010

Vancouver

Jokinen H, Kalska H, Ylikoski R, Madureira S, Verdelho A, Gouw A o.a. MRI-defined subcortical ischemic vascular disease: baseline clinical and neuropsychological findings. The LADIS Study. Cerebrovascular Diseases. 2009;27(4):336-44. https://doi.org/10.1159/000202010

Author

Jokinen, Hanna ; Kalska, Hely ; Ylikoski, Raija ; Madureira, Sofia ; Verdelho, Ana ; Gouw, Alida ; Scheltens, Philip ; Barkhof, Frederik ; Visser, Marieke C ; Fazekas, Franz ; Schmidt, Reinhold ; O'Brien, John ; Hennerici, Michael ; Baezner, Hansjorg ; Waldemar, Gunhild ; Wallin, Anders ; Chabriat, Hugues ; Pantoni, Leonardo ; Inzitari, Domenico ; Erkinjuntti, Timo ; LADIS group. / MRI-defined subcortical ischemic vascular disease: baseline clinical and neuropsychological findings. The LADIS Study. I: Cerebrovascular Diseases. 2009 ; Bind 27, Nr. 4. s. 336-44.

Bibtex

@article{c36a1cf068a811df928f000ea68e967b,
title = "MRI-defined subcortical ischemic vascular disease: baseline clinical and neuropsychological findings. The LADIS Study",
abstract = "BACKGROUND: Subcortical ischemic vascular disease (SIVD) is a common, but often overlooked cause of vascular cognitive impairment. Diagnostic research criteria for SIVD are based on magnetic resonance imaging (MRI) findings including substantial white matter lesions (WML) and multiple lacunar infarcts. Empirical studies validating these imaging criteria are still few. The purpose of the study was to describe the clinical and cognitive characteristics of the MRI-defined SIVD in a mixed sample of functionally independent elderly subjects with WML. METHODS: The subjects of the Leukoaraiosis and Disability (LADIS) study, aged 65-84 years, underwent comprehensive clinical and neuropsychological examinations, and brain MRI at the baseline assessment. The subjects meeting the SIVD imaging criteria (n = 89) were compared to the other subjects of the sample (n = 524). RESULTS: SIVD was associated with lower education, hypertension and, independently, with obesity. The subjects with SIVD had more often motor impairment, a history of falls, and subtle impairment in activities of daily living, but they did not differ for depressive symptoms. SIVD subjects performed significantly inferiorly in tests of global cognitive function, psychomotor speed, attention and executive functions, verbal fluency, and working memory. CONCLUSION: In this population of nondisabled older adults with WML, SIVD was related to specific clinical and functional characteristics. Neuropsychological features included psychomotor slowing as well as deficits in attention and executive functions.",
author = "Hanna Jokinen and Hely Kalska and Raija Ylikoski and Sofia Madureira and Ana Verdelho and Alida Gouw and Philip Scheltens and Frederik Barkhof and Visser, {Marieke C} and Franz Fazekas and Reinhold Schmidt and John O'Brien and Michael Hennerici and Hansjorg Baezner and Gunhild Waldemar and Anders Wallin and Hugues Chabriat and Leonardo Pantoni and Domenico Inzitari and Timo Erkinjuntti and {LADIS group}",
note = "Keywords: Activities of Daily Living; Aged; Aged, 80 and over; Brain; Cognition; Dementia, Vascular; Disability Evaluation; Educational Status; Europe; Female; Humans; Hypertension; Longitudinal Studies; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Obesity; Psychomotor Performance",
year = "2009",
doi = "10.1159/000202010",
language = "English",
volume = "27",
pages = "336--44",
journal = "Cerebrovascular Diseases",
issn = "1015-9770",
publisher = "S Karger AG",
number = "4",

}

RIS

TY - JOUR

T1 - MRI-defined subcortical ischemic vascular disease: baseline clinical and neuropsychological findings. The LADIS Study

AU - Jokinen, Hanna

AU - Kalska, Hely

AU - Ylikoski, Raija

AU - Madureira, Sofia

AU - Verdelho, Ana

AU - Gouw, Alida

AU - Scheltens, Philip

AU - Barkhof, Frederik

AU - Visser, Marieke C

AU - Fazekas, Franz

AU - Schmidt, Reinhold

AU - O'Brien, John

AU - Hennerici, Michael

AU - Baezner, Hansjorg

AU - Waldemar, Gunhild

AU - Wallin, Anders

AU - Chabriat, Hugues

AU - Pantoni, Leonardo

AU - Inzitari, Domenico

AU - Erkinjuntti, Timo

AU - LADIS group

N1 - Keywords: Activities of Daily Living; Aged; Aged, 80 and over; Brain; Cognition; Dementia, Vascular; Disability Evaluation; Educational Status; Europe; Female; Humans; Hypertension; Longitudinal Studies; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Obesity; Psychomotor Performance

PY - 2009

Y1 - 2009

N2 - BACKGROUND: Subcortical ischemic vascular disease (SIVD) is a common, but often overlooked cause of vascular cognitive impairment. Diagnostic research criteria for SIVD are based on magnetic resonance imaging (MRI) findings including substantial white matter lesions (WML) and multiple lacunar infarcts. Empirical studies validating these imaging criteria are still few. The purpose of the study was to describe the clinical and cognitive characteristics of the MRI-defined SIVD in a mixed sample of functionally independent elderly subjects with WML. METHODS: The subjects of the Leukoaraiosis and Disability (LADIS) study, aged 65-84 years, underwent comprehensive clinical and neuropsychological examinations, and brain MRI at the baseline assessment. The subjects meeting the SIVD imaging criteria (n = 89) were compared to the other subjects of the sample (n = 524). RESULTS: SIVD was associated with lower education, hypertension and, independently, with obesity. The subjects with SIVD had more often motor impairment, a history of falls, and subtle impairment in activities of daily living, but they did not differ for depressive symptoms. SIVD subjects performed significantly inferiorly in tests of global cognitive function, psychomotor speed, attention and executive functions, verbal fluency, and working memory. CONCLUSION: In this population of nondisabled older adults with WML, SIVD was related to specific clinical and functional characteristics. Neuropsychological features included psychomotor slowing as well as deficits in attention and executive functions.

AB - BACKGROUND: Subcortical ischemic vascular disease (SIVD) is a common, but often overlooked cause of vascular cognitive impairment. Diagnostic research criteria for SIVD are based on magnetic resonance imaging (MRI) findings including substantial white matter lesions (WML) and multiple lacunar infarcts. Empirical studies validating these imaging criteria are still few. The purpose of the study was to describe the clinical and cognitive characteristics of the MRI-defined SIVD in a mixed sample of functionally independent elderly subjects with WML. METHODS: The subjects of the Leukoaraiosis and Disability (LADIS) study, aged 65-84 years, underwent comprehensive clinical and neuropsychological examinations, and brain MRI at the baseline assessment. The subjects meeting the SIVD imaging criteria (n = 89) were compared to the other subjects of the sample (n = 524). RESULTS: SIVD was associated with lower education, hypertension and, independently, with obesity. The subjects with SIVD had more often motor impairment, a history of falls, and subtle impairment in activities of daily living, but they did not differ for depressive symptoms. SIVD subjects performed significantly inferiorly in tests of global cognitive function, psychomotor speed, attention and executive functions, verbal fluency, and working memory. CONCLUSION: In this population of nondisabled older adults with WML, SIVD was related to specific clinical and functional characteristics. Neuropsychological features included psychomotor slowing as well as deficits in attention and executive functions.

U2 - 10.1159/000202010

DO - 10.1159/000202010

M3 - Journal article

C2 - 19218799

VL - 27

SP - 336

EP - 344

JO - Cerebrovascular Diseases

JF - Cerebrovascular Diseases

SN - 1015-9770

IS - 4

ER -

ID: 19977846