Forskning ved Københavns Universitet - Københavns Universitet


MT1-mmp: a collagenase essential for tumor cell invasive growth

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The manuscript discussed in this preview describes that reconstituted three-dimensional extracellular matrices such as fibrillar collagen and fibrin exert stringent territorial growth control on cells. The authors show that tumor cells are able to escape the matrix-enforced growth control effect (entrapment) by pericellular proteolysis mediated by MT1-MMP, a membrane bound matrix metalloproteinase capable of directly cleaving both type I collagen and fibrin but not by other, soluble matrix metalloprotinases. These data convincingly demonstrate one way that tumor cells orchestrate proteolysis to invade surrounding tissues.

TidsskriftCancer Cell
Udgave nummer2
Sider (fra-til)83-4
Antal sider2
StatusUdgivet - aug. 2003

ID: 201164585