Forskning ved Københavns Universitet - Københavns Universitet

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Mucosal surface morphology and histological changes in the duodenum of the rat following administration of cysteamine

Publikation: Forskning - peer reviewTidsskriftartikel

Acute duodenal ulcer can be produced in the rat by subcutaneous or oral administration of cysteamine. Development of this ulcer on the intestinal mucosal surface was followed from precursory stages to perforation using low power semimacroscopical and conventional histological techniques. The process started in the epithelium of the apical parts of the villi where segments of surface epithelial cells exfoliated and the lamina propria seemed to retract. As the process continued the villi gradually became lower eventually forming an avillous surface. Subsequently defects in the epithelium, necrosis, inflammation of the lamina propria, and a localized ulcer developed.
OriginalsprogEngelsk
TidsskriftBritish journal of experimental pathology
Vol/bind58
Tidsskriftsnummer1
Sider (fra-til)1-8
Antal sider8
ISSN0007-1021
StatusUdgivet - feb. 1977

ID: 47490247