Forskning ved Københavns Universitet - Københavns Universitet

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Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration

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  • Raymond Noordam
  • Maxime M Bos
  • Heming Wang
  • Thomas W Winkler
  • Amy R Bentley
  • Paul S de Vries
  • Yun Ju Sung
  • Karen Schwander
  • Brian E Cade
  • Alisa Manning
  • Hugues Aschard
  • Michael R Brown
  • Han Chen
  • Nora Franceschini
  • Solomon K Musani
  • Melissa Richard
  • Dina Vojinovic
  • Stella Aslibekyan
  • Traci M Bartz
  • Lisa de Las Fuentes
  • Mary Feitosa
  • Andrea R Horimoto
  • Marjan Ilkov
  • Minjung Kho
  • Aldi Kraja
  • Changwei Li
  • Elise Lim
  • Yongmei Liu
  • Dennis O Mook-Kanamori
  • Tuomo Rankinen
  • Salman M Tajuddin
  • Ashley van der Spek
  • Zhe Wang
  • Jonathan Marten
  • Vincent Laville
  • Maris Alver
  • Evangelos Evangelou
  • Maria E Graff
  • Meian He
  • Brigitte Kühnel
  • Leo-Pekka Lyytikäinen
  • Pedro Marques-Vidal
  • Ilja M Nolte
  • Nicholette D Palmer
  • Rainer Rauramaa
  • Xiao-Ou Shu
  • Harold Snieder
  • Stefan Weiss
  • Wanqing Wen
  • Lisa R Yanek
  • Correa Adolfo
  • Christie Ballantyne
  • Larry Bielak
  • Nienke R Biermasz
  • Eric Boerwinkle
  • Niki Dimou
  • Gudny Eiriksdottir
  • Chuan Gao
  • Sina A Gharib
  • Daniel J Gottlieb
  • José Haba-Rubio
  • Tamara B Harris
  • Sami Heikkinen
  • Raphaël Heinzer
  • James E Hixson
  • Georg Homuth
  • M Arfan Ikram
  • Pirjo Komulainen
  • Jose E Krieger
  • Jiwon Lee
  • Jingmin Liu
  • Kurt K Lohman
  • Annemarie I Luik
  • Reedik Mägi
  • Lisa W Martin
  • Thomas Meitinger
  • Andres Metspalu
  • Yuri Milaneschi
  • Mike A Nalls
  • Jeff O'Connell
  • Annette Peters
  • Patricia Peyser
  • Olli T Raitakari
  • Alex P Reiner
  • Patrick C N Rensen
  • Treva K Rice
  • Stephen S Rich
  • Till Roenneberg
  • Jerome I Rotter
  • Pamela J Schreiner
  • James Shikany
  • Stephen S Sidney
  • Mario Sims
  • Colleen M Sitlani
  • Tamar Sofer
  • Konstantin Strauch
  • Morris A Swertz
  • Kent D Taylor
  • André G Uitterlinden
  • Cornelia M van Duijn
  • Henry Völzke
  • Melanie Waldenberger
  • Robert B Wallance
  • Ko Willems van Dijk
  • Caizheng Yu
  • Alan B Zonderman
  • Diane M Becker
  • Paul Elliott
  • Tõnu Esko
  • Christian Gieger
  • Hans J Grabe
  • Timo A Lakka
  • Terho Lehtimäki
  • Kari E North
  • Brenda W J H Penninx
  • Peter Vollenweider
  • Lynne E Wagenknecht
  • Tangchun Wu
  • Yong-Bing Xiang
  • Wei Zheng
  • Donna K Arnett
  • Claude Bouchard
  • Michele K Evans
  • Vilmundur Gudnason
  • Sharon Kardia
  • Tanika N Kelly
  • Stephen B Kritchevsky
  • Ruth J F Loos
  • Alexandre C Pereira
  • Mike Province
  • Bruce M Psaty
  • Charles Rotimi
  • Xiaofeng Zhu
  • Najaf Amin
  • L Adrienne Cupples
  • Myriam Fornage
  • Ervin F Fox
  • Xiuqing Guo
  • W James Gauderman
  • Kenneth Rice
  • Charles Kooperberg
  • Patricia B Munroe
  • Ching-Ti Liu
  • Alanna C Morrison
  • Dabeeru C Rao
  • Diana van Heemst
  • Susan Redline

Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identify 49 previously unreported lipid loci, and 10 additional previously unreported lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identify new gene-sleep interactions for known lipid loci such as LPL and PCSK9. The previously unreported lipid loci have a modest explained variance in lipid levels: most notable, gene-short-sleep interactions explain 4.25% of the variance in triglyceride level. Collectively, these findings contribute to our understanding of the biological mechanisms involved in sleep-associated adverse lipid profiles.

OriginalsprogEngelsk
Artikelnummer5121
TidsskriftNature Communications
Vol/bind10
Udgave nummer1
Antal sider13
ISSN2041-1723
DOI
StatusUdgivet - 2019

ID: 230439617