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Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system

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T-cell accumulation in the central nervous system (CNS) is considered crucial to the pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the cerebrospinal fluid (CSF) compartment expressed the CXC chemokine receptor 3 (CXCR), independent of CNS inflammation. Quantitative immunohistochemistry revealed continuous accumulation of CXCR3+ T cells during MS lesion formation. The expression of one CXCR3 ligand, interferon (IFN)-gamma-inducible protein of 10 kDa (IP-10)/CXC chemokine ligand (CXCL) 10 was elevated in MS CSF, spatially associated with demyelination in CNS tissue sections and correlated tightly with CXCR3 expression. These data suggest a critical role for CXCL10 and CXCR3 in the accumulation of T cells in the CNS of MS patients.
OriginalsprogEngelsk
TidsskriftJournal of Neuroimmunology
Vol/bind127
Udgave nummer1-2
Sider (fra-til)59-68
Antal sider10
ISSN0165-5728
StatusUdgivet - jun. 2002

ID: 111410582