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Mutations in the AXIN1 gene in advanced prostate cancer

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • George W Yardy
  • David C Bicknell
  • Jennifer L Wilding
  • Sylvia Bartlett
  • Liu, Ying
  • Bruce Winney
  • Gareth D H Turner
  • Simon F Brewster
  • Walter F Bodmer
The Wnt signalling pathway directs aspects of embryogenesis and is thought to contribute to maintenance of certain stem cell populations. Disruption of the pathway has been observed in many different tumour types. In bowel, stomach, and endometrial cancer, this is usually due to mutation of genes encoding Wnt pathway components APC or beta-catenin. Such mutations are rare in hepatocellular carcinomas and medulloblastomas with Wnt pathway dysfunction, and there, mutation in genes for other Wnt molecules, such as Axin, is more frequently found.
OriginalsprogEngelsk
TidsskriftEuropean Urology Supplements
Vol/bind56
Udgave nummer3
Sider (fra-til)486-94
Antal sider9
ISSN1569-9056
DOI
StatusUdgivet - 1 sep. 2009

ID: 33572511