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Natalamycin A, an ansamycin from a termite-associated Streptomyces sp.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Ki Hyun Kim
  • Timothy R. Ramadhar
  • Christine Beemelmanns
  • Shugeng Cao
  • Poulsen, Michael
  • Cameron R. Currie
  • Jon Clardy

We report a preliminary functional and complete structural characterization of a highly unusual geldanamycin analog, natalamycin A, that was isolated from Streptomyces strain M56 recovered from a South African nest of Macrotermes natalensis termites. Bioassay-guided fractionation based on antifungal activity led to the isolation of natalamycin A, and a combination of NMR spectroscopy and X-ray crystallographic analysis, including highly-accurate quantum-chemical NMR calculations on the largest and most conformationally-flexible system to date, revealed natalamycin A's three-dimensional solid- and solution-state structure. This structure along with the structures of related compounds isolated from the same source suggest a geldanamycin-like biosynthetic pathway with unusual post-PKS modifications.

OriginalsprogEngelsk
TidsskriftChemical Science
Vol/bind5
Sider (fra-til)4333-4338
Antal sider6
ISSN2041-6520
DOI
StatusUdgivet - 2014

ID: 136190318