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Non-invasive study of nerve fibres using laser interference microscopy

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Alexey Brazhe
  • Nadezda Brazhe
  • N N Rodionova
  • A I Yusipovich
  • P S Ignatyev
  • G V Maksimov
  • Erik Mosekilde
  • Sosnovtseva, Olga
This paper presents the results of a laser interference microscopy study of the morphology and dynamical properties of myelinated nerve fibres. We describe the principles of operation of the phase-modulated laser interference microscope and show how this novel technique allows us to obtain information non-invasively about the internal structure of different regions of a nerve fibre. We also analyse the temporal variations in the internal optical properties in order to detect the rhythmic activity in the nerve fibre at different time scales and to shed light on the underlying biological processes. We observe pronounced frequencies in the dynamics of the optical properties and suggest that the oscillatory modes have similar origin in different regions, but different strengths and mutual modulation properties.
OriginalsprogEngelsk
TidsskriftRoyal Society of London. Philosophical Transactions. Mathematical, Physical and Engineering Sciences
Vol/bind366
Udgave nummer1880
Sider (fra-til)3463-81
Antal sider19
ISSN1364-503X
DOI
StatusUdgivet - 13 okt. 2008

ID: 33812380