Forskning ved Københavns Universitet - Københavns Universitet

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Novel and future treatment strategies

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningfagfællebedømt

The biofilm mode of life is by many scientists acknowledged as a successful, bacterial survival strategy in hostile environments. When bacteria invade their hosts, they encounter harsh conditions such as low levels of iron, oxidative stress, macerating enzymes, phagocytic cells, and host-derived as well as administered antimicrobials. Experimental evidence has accumulated over the years showing that biofilms tolerate antimicrobial properties of the immune system and antibiotics. This multifaceted tolerance relies to a certain extend on general resistance mechanisms including efflux pumps and enzymatic modifications in addition to innate tolerances offered by integral structure-functions of the biofilm.

OriginalsprogEngelsk
TitelBiofilm Infections
Antal sider19
ForlagSpringer
Publikationsdato1 dec. 2011
Sider231-249
ISBN (Trykt)9781441960832
DOI
StatusUdgivet - 1 dec. 2011

ID: 201670826