Forskning ved Københavns Universitet - Københavns Universitet


On the etiology of incident brain lacunes: longitudinal observations from the LADIS study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • A.A. Gouw
  • W.M. van der Flier
  • L. Pantoni
  • D. Inzitari
  • T. Erkinjuntti
  • L.O. Wahlund
  • Waldemar, Gunhild
  • R. Schmidt
  • F. Fazekas
  • P. Scheltens
  • F. Barkhof
BACKGROUND AND PURPOSE: We investigated regional differences in MRI characteristics and risk factor profiles of incident lacunes over a 3-year period. METHODS: Baseline and 3-year follow-up MRI were collected within the LADIS study (n=358). Incident lacunes were characterized with respect to brain region, their appearance within pre-existent white matter hyperintensities (WMH), surrounding WMH size, and risk factors. RESULTS: 106 incident lacunes were observed in 62 patients (58 subcortical white matter [WM], 35 basal ganglia, and 13 infratentorial). Incident subcortical WM lacunes occurred more often within preexisting WMH (P=0.01) and were mostly accompanied by new and expanded WMH (P<0.001), compared to incident basal ganglia and infratentorial lacunes. Risk factors for incident subcortical WM lacunes were history of hypertension and stroke, whereas atrial fibrillation predicted incident basal ganglia/infratentorial lacunes. CONCLUSIONS: Differences in relation to WMH and risk factor profiles may suggest that incident lacunes in the subcortical WM have a different pathogenesis than those in the basal ganglia and infratentorial region
Udgivelsesdato: 2008/11
Udgave nummer11
Sider (fra-til)3083-3085
Antal sider2
StatusUdgivet - 2008

ID: 14150626