Forskning ved Københavns Universitet - Københavns Universitet

Forside

Osmium carbonyl clusters: a new class of apoptosis inducing agents

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Kien Voon Kong
  • Weng Kee Leong
  • Swee Phyaw Ng
  • Thanh Hung Nguyen
  • Lina H K Lim

Osmium carbonyl clusters, especially the cluster [Os(3)(CO)(10)(NCCH(3))(2)], were found to be active against four cancer cell lines, namely, ER+ breast carcinoma (MCF-7), ER- breast carcinoma (MDA-MB-231), metastatic colorectal adenocarcinoma (SW620), and hepatocarcinoma (Hep G2). The mode of action was studied in MCF-7 and MDA-MB-231 cell lines by a number of morphological and apoptosis assays, all of which pointed to the induction of apoptosis.

OriginalsprogEngelsk
TidsskriftChemMedChem
Vol/bind3
Udgave nummer8
Sider (fra-til)1269-75
Antal sider7
DOI
StatusUdgivet - aug. 2008
Eksternt udgivetJa

ID: 120743426