Forskning ved Københavns Universitet - Københavns Universitet

Forside

p53 codon 72 polymorphic variants, loss of allele-specific transcription, and human papilloma virus 16 and/or 18 E6 messenger RNA expression in squamous cell carcinomas of the head and neck

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

p53 codon 72 polymorphic variants, loss of allele-specific transcription, and human papilloma virus 16 and/or 18 E6 messenger RNA expression in squamous cell carcinomas of the head and neck. / Scheckenbach, Kathrin; Dr Lieven, Oliver Wilm; Götte, Karl; Bockmühl, Ulrike; Zotz, Rainer; Bier, Henning; Balz, Vera.

I: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Bind 13, Nr. 11 Pt 1, 11.2004, s. 1805-9.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Scheckenbach, K, Dr Lieven, OW, Götte, K, Bockmühl, U, Zotz, R, Bier, H & Balz, V 2004, 'p53 codon 72 polymorphic variants, loss of allele-specific transcription, and human papilloma virus 16 and/or 18 E6 messenger RNA expression in squamous cell carcinomas of the head and neck', Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, bind 13, nr. 11 Pt 1, s. 1805-9.

APA

Scheckenbach, K., Dr Lieven, O. W., Götte, K., Bockmühl, U., Zotz, R., Bier, H., & Balz, V. (2004). p53 codon 72 polymorphic variants, loss of allele-specific transcription, and human papilloma virus 16 and/or 18 E6 messenger RNA expression in squamous cell carcinomas of the head and neck. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 13(11 Pt 1), 1805-9.

Vancouver

Scheckenbach K, Dr Lieven OW, Götte K, Bockmühl U, Zotz R, Bier H o.a. p53 codon 72 polymorphic variants, loss of allele-specific transcription, and human papilloma virus 16 and/or 18 E6 messenger RNA expression in squamous cell carcinomas of the head and neck. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2004 nov;13(11 Pt 1):1805-9.

Author

Scheckenbach, Kathrin ; Dr Lieven, Oliver Wilm ; Götte, Karl ; Bockmühl, Ulrike ; Zotz, Rainer ; Bier, Henning ; Balz, Vera. / p53 codon 72 polymorphic variants, loss of allele-specific transcription, and human papilloma virus 16 and/or 18 E6 messenger RNA expression in squamous cell carcinomas of the head and neck. I: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2004 ; Bind 13, Nr. 11 Pt 1. s. 1805-9.

Bibtex

@article{b26304c732e24bca927b31a46517705b,
title = "p53 codon 72 polymorphic variants, loss of allele-specific transcription, and human papilloma virus 16 and/or 18 E6 messenger RNA expression in squamous cell carcinomas of the head and neck",
abstract = "A polymorphism at codon 72 of the human tumor suppressor p53 determines translation into either arginine or proline. Yet, the impact of this amino acid variability on the risk to develop malignant tumors, particularly carcinomas associated with human papilloma virus (HPV) infections, remains unresolved because of contradictory results. To address a potential correlation between the different genotypes and the manifestation of squamous cell carcinomas of the head and neck (SCCHN), we determined the p53 codon 72 in 193 healthy subjects and 122 unselected SCCHN with known HPV status. Furthermore, loss of allele-specific transcription was analyzed in p53 codon 72 heterozygous (Arg/Pro) SCCHN and correlated with HPV 16 and/or 18 E6 transcript expression. We found a moderately increased risk (odds ratio, 1.86; 95{\%} confidence interval, 1.0-3.3) for individuals with germ line heterozygosity to develop SCC of the pharynx. On the other hand, p53 codon 72 polymorphic variants, most notably the Arg/Arg genotype, showed no association with the presence of HPV 16 and/or 18 E6 transcript. Moreover, there was no evidence for HPV-driven selection in SCCHN with allele-specific loss of transcription. Our data suggest that the p53 codon 72 polymorphism has a minor impact on the development of SCCHN.",
keywords = "Adult, Aged, Carcinoma, Squamous Cell, Case-Control Studies, Female, Genotype, Head and Neck Neoplasms, Humans, Male, Middle Aged, Oncogene Proteins, Viral, Polymorphism, Genetic, RNA, Messenger, Tumor Suppressor Protein p53",
author = "Kathrin Scheckenbach and {Dr Lieven}, {Oliver Wilm} and Karl G{\"o}tte and Ulrike Bockm{\"u}hl and Rainer Zotz and Henning Bier and Vera Balz",
year = "2004",
month = "11",
language = "English",
volume = "13",
pages = "1805--9",
journal = "Cancer Epidemiology, Biomarkers & Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research (A A C R)",
number = "11 Pt 1",

}

RIS

TY - JOUR

T1 - p53 codon 72 polymorphic variants, loss of allele-specific transcription, and human papilloma virus 16 and/or 18 E6 messenger RNA expression in squamous cell carcinomas of the head and neck

AU - Scheckenbach, Kathrin

AU - Dr Lieven, Oliver Wilm

AU - Götte, Karl

AU - Bockmühl, Ulrike

AU - Zotz, Rainer

AU - Bier, Henning

AU - Balz, Vera

PY - 2004/11

Y1 - 2004/11

N2 - A polymorphism at codon 72 of the human tumor suppressor p53 determines translation into either arginine or proline. Yet, the impact of this amino acid variability on the risk to develop malignant tumors, particularly carcinomas associated with human papilloma virus (HPV) infections, remains unresolved because of contradictory results. To address a potential correlation between the different genotypes and the manifestation of squamous cell carcinomas of the head and neck (SCCHN), we determined the p53 codon 72 in 193 healthy subjects and 122 unselected SCCHN with known HPV status. Furthermore, loss of allele-specific transcription was analyzed in p53 codon 72 heterozygous (Arg/Pro) SCCHN and correlated with HPV 16 and/or 18 E6 transcript expression. We found a moderately increased risk (odds ratio, 1.86; 95% confidence interval, 1.0-3.3) for individuals with germ line heterozygosity to develop SCC of the pharynx. On the other hand, p53 codon 72 polymorphic variants, most notably the Arg/Arg genotype, showed no association with the presence of HPV 16 and/or 18 E6 transcript. Moreover, there was no evidence for HPV-driven selection in SCCHN with allele-specific loss of transcription. Our data suggest that the p53 codon 72 polymorphism has a minor impact on the development of SCCHN.

AB - A polymorphism at codon 72 of the human tumor suppressor p53 determines translation into either arginine or proline. Yet, the impact of this amino acid variability on the risk to develop malignant tumors, particularly carcinomas associated with human papilloma virus (HPV) infections, remains unresolved because of contradictory results. To address a potential correlation between the different genotypes and the manifestation of squamous cell carcinomas of the head and neck (SCCHN), we determined the p53 codon 72 in 193 healthy subjects and 122 unselected SCCHN with known HPV status. Furthermore, loss of allele-specific transcription was analyzed in p53 codon 72 heterozygous (Arg/Pro) SCCHN and correlated with HPV 16 and/or 18 E6 transcript expression. We found a moderately increased risk (odds ratio, 1.86; 95% confidence interval, 1.0-3.3) for individuals with germ line heterozygosity to develop SCC of the pharynx. On the other hand, p53 codon 72 polymorphic variants, most notably the Arg/Arg genotype, showed no association with the presence of HPV 16 and/or 18 E6 transcript. Moreover, there was no evidence for HPV-driven selection in SCCHN with allele-specific loss of transcription. Our data suggest that the p53 codon 72 polymorphism has a minor impact on the development of SCCHN.

KW - Adult

KW - Aged

KW - Carcinoma, Squamous Cell

KW - Case-Control Studies

KW - Female

KW - Genotype

KW - Head and Neck Neoplasms

KW - Humans

KW - Male

KW - Middle Aged

KW - Oncogene Proteins, Viral

KW - Polymorphism, Genetic

KW - RNA, Messenger

KW - Tumor Suppressor Protein p53

M3 - Journal article

C2 - 15533911

VL - 13

SP - 1805

EP - 1809

JO - Cancer Epidemiology, Biomarkers & Prevention

JF - Cancer Epidemiology, Biomarkers & Prevention

SN - 1055-9965

IS - 11 Pt 1

ER -

ID: 46778943