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Pain, sedation and morphine metabolism in cancer patients during long-term treatment with sustained-release morphine

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Morphine-6-glucuronide (M-6-G) and morphine-3-glucuronide (M-3-G) are the two most important metabolites of morphine. Both are pharmacologically active, however, with different effects. M-6-G has been demonstrated capable of inducing anti-nociception and sedation, and M-3-G may induce behavioural excitation and possibly antagonise anti-nociception. Their impact on pharmacodynamics in patients in long-term treatment with oral morphine remains to be settled.
OriginalsprogEngelsk
TidsskriftPalliative Medicine
Vol/bind16
Udgave nummer2
Sider (fra-til)107-14
Antal sider8
ISSN0269-2163
StatusUdgivet - mar. 2002
Eksternt udgivetJa

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