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Pancreatic polypeptide is involved in the regulation of body weight in pima Indian male subjects

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Standard

Pancreatic polypeptide is involved in the regulation of body weight in pima Indian male subjects. / Koska, Juraj; DelParigi, Angelo; de Courten, Barbora; Weyer, Christian; Tataranni, P Antonio.

I: Diabetes, Bind 53, Nr. 12, 01.12.2004, s. 3091-6.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Koska, J, DelParigi, A, de Courten, B, Weyer, C & Tataranni, PA 2004, 'Pancreatic polypeptide is involved in the regulation of body weight in pima Indian male subjects', Diabetes, bind 53, nr. 12, s. 3091-6.

APA

Koska, J., DelParigi, A., de Courten, B., Weyer, C., & Tataranni, P. A. (2004). Pancreatic polypeptide is involved in the regulation of body weight in pima Indian male subjects. Diabetes, 53(12), 3091-6.

Vancouver

Koska J, DelParigi A, de Courten B, Weyer C, Tataranni PA. Pancreatic polypeptide is involved in the regulation of body weight in pima Indian male subjects. Diabetes. 2004 dec 1;53(12):3091-6.

Author

Koska, Juraj ; DelParigi, Angelo ; de Courten, Barbora ; Weyer, Christian ; Tataranni, P Antonio. / Pancreatic polypeptide is involved in the regulation of body weight in pima Indian male subjects. I: Diabetes. 2004 ; Bind 53, Nr. 12. s. 3091-6.

Bibtex

@article{d43a278e231f4d80b1fc9de420a54dc1,
title = "Pancreatic polypeptide is involved in the regulation of body weight in pima Indian male subjects",
abstract = "Pancreatic polypeptide (PP) is released from the pancreas in response to a meal. In humans, low-circulating PP levels have been observed in obesity, and administration of pharmacological doses of PP has been shown to decrease food intake. The aim of the present study was to investigate whether low circulating PP is associated with weight gain in Pima Indians. Plasma PP concentrations were measured after an overnight fast and 30 min after a standardized mixed meal in 33 nondiabetic male subjects who had a follow-up visit 4.9 +/- 2.5 years later. Cross-sectionally, fasting and postprandial PP levels were negatively associated with body size and adiposity. Prospectively, the change in PP response to the meal was negatively associated with the change in body weight (r = -0.53, P = 0.002). In contrast, a high fasting PP level was positively associated with change in body weight (r = 0.45, P = 0.009). In conclusion, our results provide evidence that, even within the physiological range, PP contributes to the regulation of energy balance in humans. However this contribution appears to be more complex than anticipated because of the opposite effect of fasting and postprandial PP on the risk of future weight gain.",
keywords = "Adult, Arizona, Body Mass Index, Body Weight, Eating, Energy Metabolism, Fasting, Homeostasis, Humans, Indians, North American, Male, Pancreatic Polypeptide, Postprandial Period",
author = "Juraj Koska and Angelo DelParigi and {de Courten}, Barbora and Christian Weyer and Tataranni, {P Antonio}",
year = "2004",
month = "12",
day = "1",
language = "English",
volume = "53",
pages = "3091--6",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association",
number = "12",

}

RIS

TY - JOUR

T1 - Pancreatic polypeptide is involved in the regulation of body weight in pima Indian male subjects

AU - Koska, Juraj

AU - DelParigi, Angelo

AU - de Courten, Barbora

AU - Weyer, Christian

AU - Tataranni, P Antonio

PY - 2004/12/1

Y1 - 2004/12/1

N2 - Pancreatic polypeptide (PP) is released from the pancreas in response to a meal. In humans, low-circulating PP levels have been observed in obesity, and administration of pharmacological doses of PP has been shown to decrease food intake. The aim of the present study was to investigate whether low circulating PP is associated with weight gain in Pima Indians. Plasma PP concentrations were measured after an overnight fast and 30 min after a standardized mixed meal in 33 nondiabetic male subjects who had a follow-up visit 4.9 +/- 2.5 years later. Cross-sectionally, fasting and postprandial PP levels were negatively associated with body size and adiposity. Prospectively, the change in PP response to the meal was negatively associated with the change in body weight (r = -0.53, P = 0.002). In contrast, a high fasting PP level was positively associated with change in body weight (r = 0.45, P = 0.009). In conclusion, our results provide evidence that, even within the physiological range, PP contributes to the regulation of energy balance in humans. However this contribution appears to be more complex than anticipated because of the opposite effect of fasting and postprandial PP on the risk of future weight gain.

AB - Pancreatic polypeptide (PP) is released from the pancreas in response to a meal. In humans, low-circulating PP levels have been observed in obesity, and administration of pharmacological doses of PP has been shown to decrease food intake. The aim of the present study was to investigate whether low circulating PP is associated with weight gain in Pima Indians. Plasma PP concentrations were measured after an overnight fast and 30 min after a standardized mixed meal in 33 nondiabetic male subjects who had a follow-up visit 4.9 +/- 2.5 years later. Cross-sectionally, fasting and postprandial PP levels were negatively associated with body size and adiposity. Prospectively, the change in PP response to the meal was negatively associated with the change in body weight (r = -0.53, P = 0.002). In contrast, a high fasting PP level was positively associated with change in body weight (r = 0.45, P = 0.009). In conclusion, our results provide evidence that, even within the physiological range, PP contributes to the regulation of energy balance in humans. However this contribution appears to be more complex than anticipated because of the opposite effect of fasting and postprandial PP on the risk of future weight gain.

KW - Adult

KW - Arizona

KW - Body Mass Index

KW - Body Weight

KW - Eating

KW - Energy Metabolism

KW - Fasting

KW - Homeostasis

KW - Humans

KW - Indians, North American

KW - Male

KW - Pancreatic Polypeptide

KW - Postprandial Period

M3 - Journal article

C2 - 15561938

VL - 53

SP - 3091

EP - 3096

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 12

ER -

ID: 33925507