Forskning ved Københavns Universitet - Københavns Universitet


Pancreatic tissue fluid pressure in chronic pancreatitis. Relation to pain, morphology, and function.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

  • N Ebbehøj
  • L Borly
  • J Bülow
  • S G Rasmussen
  • P Madsen
  • Peter Matzen
  • A Owre
The relation between pancreatic tissue fluid pressure and pain, morphology, and function was studied in a cross-sectional investigation. Pressure measurements were performed by percutaneous fine-needle puncture. Thirty-nine patients with chronic pancreatitis were included, 25 with pain and 14 without pain. The pressure was higher in patients with pain than in patients without pain (p = 0.000001), and this was significantly related to a pain score from a visual analogue scale (p less than 0.001). Patients with pancreatic pseudocysts had both higher pressure and higher pain score than patients without (p = 0.004 and p = 0.0003, respectively). The pressure was significantly related (inversely) to pancreatic duct diameter only in the group of 19 patients with earlier pancreatic surgery (R = -0.57, p = 0.02). The pressure was not related to functional factors or the presence of pancreatic calcifications. In conclusion, pancreatic tissue fluid pressure is a valuable indicator of pain in chronic pancreatitis.
TidsskriftScandinavian Journal of Gastroenterology
Udgave nummer10
Sider (fra-til)1046-1051
Antal sider6
StatusUdgivet - 1990

ID: 34189350