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Peptide nucleic acids and their potential applications in biotechnology

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Peptide nucleic acids (PNAs) are novel DNA mimics in which the sugar-phosphate backbone has been replaced with a backbone based on amino acids. PNAs exhibit sequence-specific binding to DNA and RNA with higher affinities and specificities than unmodified DNA. They are resistant to nuclease and protease attack in serum and cellular extracts and, thus, appear very promising as diagnostic and biomolecular probes, and possibly as antisense and antigene drugs.

OriginalsprogEngelsk
TidsskriftTrends in Biotechnology
Vol/bind11
Udgave nummer9
Sider (fra-til)384-6
Antal sider3
ISSN0167-7799
DOI
StatusUdgivet - sep. 1993

ID: 203630719