Forskning ved Københavns Universitet - Københavns Universitet


Perspective: Metabotyping - A potential personalized nutrition strategy for precision prevention of cardiometabolic disease

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Marie Palmnäs
  • Carl Brunius
  • Lin Shi
  • Rostgaard-Hansen, Agnetha Linn
  • Núria Estanyol Torres
  • Raúl González-Domínguez
  • Raul Zamora-Ros
  • Ye Lingqun Ye
  • Jytte Halkjær
  • Tjønneland, Anne
  • Gabriele Riccardi
  • Rosalba Giacco
  • Giuseppina Costabile
  • Claudia Vetrani
  • Jens Nielsen
  • Cristina Andres-Lacueva
  • Rikard Landberg

Diet is an important, modifiable lifestyle factor of cardiometabolic disease risk, and an improved diet can delay or even prevent the onset of disease. Recent evidence suggests that individuals could benefit from diets adapted to their genotype and phenotype: that is, personalized nutrition. A novel strategy is to tailor diets for groups of individuals according to their metabolic phenotypes (metabotypes). Randomized controlled trials evaluating metabotype-specific responses and nonresponses are urgently needed to bridge the current gap of knowledge with regard to the efficacy of personalized strategies in nutrition. In this Perspective, we discuss the concept of metabotyping, review the current literature on metabotyping in the context of cardiometabolic disease prevention, and suggest potential strategies for metabotype-based nutritional advice for future work. We also discuss potential determinants of metabotypes, including gut microbiota, and highlight the use of metabolomics to define effective markers for cardiometabolic disease-related metabotypes. Moreover, we hypothesize that people at high risk for cardiometabolic diseases have distinct metabotypes and that individuals grouped into specific metabotypes may respond differently to the same diet, which is being tested in a project of the Joint Programming Initiative: A Healthy Diet for a Healthy Life.

TidsskriftAdvances in Nutrition
Udgave nummer3
Sider (fra-til)524-532
Antal sider9
StatusUdgivet - 2020
Eksternt udgivetJa

Bibliografisk note


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