Forskning ved Københavns Universitet - Københavns Universitet


Pharmacological Attenuation of Myocardial Reperfusion Injury in a Closed-Chest Porcine Model: a Systematic Review

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Myocardial ischemia-reperfusion injury is a clinical challenge in interventional cardiology, and at the moment, no pharmacological agent is universally accepted in the prevention. In order to prevent inappropriate clinical trials, a potential pharmacological agent should be proved reproducibly effective in clinically relevant experimental studies before initiation of human studies. The closed-chest porcine model is a promising experimental model of ischemia-reperfusion injury. The purpose of this systematic review was to describe the pharmacological treatments evaluated in the closed-chest porcine model and discuss different aspects of the model for future use. The systematic review was performed according to the PRISMA guidelines.

TidsskriftJournal of Cardiovascular Translational Research
Udgave nummer6
Sider (fra-til)570-580
Antal sider11
StatusUdgivet - aug. 2014

ID: 138137612