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Pharmacological Attenuation of Myocardial Reperfusion Injury in a Closed-Chest Porcine Model: a Systematic Review

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Myocardial ischemia-reperfusion injury is a clinical challenge in interventional cardiology, and at the moment, no pharmacological agent is universally accepted in the prevention. In order to prevent inappropriate clinical trials, a potential pharmacological agent should be proved reproducibly effective in clinically relevant experimental studies before initiation of human studies. The closed-chest porcine model is a promising experimental model of ischemia-reperfusion injury. The purpose of this systematic review was to describe the pharmacological treatments evaluated in the closed-chest porcine model and discuss different aspects of the model for future use. The systematic review was performed according to the PRISMA guidelines.

OriginalsprogEngelsk
TidsskriftJournal of Cardiovascular Translational Research
Vol/bind7
Udgave nummer6
Sider (fra-til)570-580
Antal sider11
ISSN1937-5387
DOI
StatusUdgivet - aug. 2014

ID: 138137612