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Physical stability and moisture sorption of aqueous chitosan-amylose starch films plasticized with polyols

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Standard

Physical stability and moisture sorption of aqueous chitosan-amylose starch films plasticized with polyols. / Cervera, Mirna Fernández; Karjalainen, Milja; Airaksinen, Sari; Rantanen, Jukka; Krogars, Karin; Heinämäki, Jyrki; Colarte, Antonio Iraizoz; Yliruusi, Jouko.

I: European Journal of Pharmaceutics and Biopharmaceutics, Bind 58, Nr. 1, 07.2004, s. 69-76.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Cervera, MF, Karjalainen, M, Airaksinen, S, Rantanen, J, Krogars, K, Heinämäki, J, Colarte, AI & Yliruusi, J 2004, 'Physical stability and moisture sorption of aqueous chitosan-amylose starch films plasticized with polyols', European Journal of Pharmaceutics and Biopharmaceutics, bind 58, nr. 1, s. 69-76. https://doi.org/10.1016/j.ejpb.2004.03.015

APA

Cervera, M. F., Karjalainen, M., Airaksinen, S., Rantanen, J., Krogars, K., Heinämäki, J., ... Yliruusi, J. (2004). Physical stability and moisture sorption of aqueous chitosan-amylose starch films plasticized with polyols. European Journal of Pharmaceutics and Biopharmaceutics, 58(1), 69-76. https://doi.org/10.1016/j.ejpb.2004.03.015

Vancouver

Cervera MF, Karjalainen M, Airaksinen S, Rantanen J, Krogars K, Heinämäki J o.a. Physical stability and moisture sorption of aqueous chitosan-amylose starch films plasticized with polyols. European Journal of Pharmaceutics and Biopharmaceutics. 2004 jul;58(1):69-76. https://doi.org/10.1016/j.ejpb.2004.03.015

Author

Cervera, Mirna Fernández ; Karjalainen, Milja ; Airaksinen, Sari ; Rantanen, Jukka ; Krogars, Karin ; Heinämäki, Jyrki ; Colarte, Antonio Iraizoz ; Yliruusi, Jouko. / Physical stability and moisture sorption of aqueous chitosan-amylose starch films plasticized with polyols. I: European Journal of Pharmaceutics and Biopharmaceutics. 2004 ; Bind 58, Nr. 1. s. 69-76.

Bibtex

@article{cb69b240a9504fea96f0fcafa358ed06,
title = "Physical stability and moisture sorption of aqueous chitosan-amylose starch films plasticized with polyols",
abstract = "The short-term stability and the water sorption of films prepared from binary mixtures of chitosan and native amylose maize starch (Hylon VII) were evaluated using free films. The aqueous polymer solutions of the free films contained 2{\%} (w/w) film formers, glycerol, or erythritol as a plasticizer, as well as acetic acid (1{\%}) and purified water. Characterization of the present fresh and conditioned film formers and free films was done using X-ray diffraction analysis, determination of moisture sorption isotherms, and near infrared spectroscopy. The results indicated that clear changes in the crystallinity of the films are evident within a 3-month period of storage, and the changes in the solid state are dependent on the plasticizer and storage conditions. When stored at ambient conditions for 3 months, the aqueous chitosan-amylose starch films plasticized with erythritol exhibited a partly crystalline structure. This was as a result of sugar recrystallisation due to the high hydrogen bonding. The respective films plasticized with glycerol and stored at 25 degrees C/60{\%} relative humidity (RH) or at 40 degrees C/75{\%} RH remained flexible and amorphous for at least 3 months. The water sorption of the free films greatly increased as a function of storage time at 75 and 95{\%} RH. The second derivative spectra of starting material and free films were capable of distinguishing the internal water from the free water after storage at different relative humidities. Free water resulted in a separate band at a lower wavelength (1903 nm) in comparison to the structured absorbed water band at 1920 nm, in the case of films the free water resulted in a band around 1900 nm.",
keywords = "Amylose, Chitosan, Drug Stability, Humidity, Plasticizers, Polymers, Starch",
author = "Cervera, {Mirna Fern{\'a}ndez} and Milja Karjalainen and Sari Airaksinen and Jukka Rantanen and Karin Krogars and Jyrki Hein{\"a}m{\"a}ki and Colarte, {Antonio Iraizoz} and Jouko Yliruusi",
note = "Copyright 2004 Elsevier B.V.",
year = "2004",
month = "7",
doi = "10.1016/j.ejpb.2004.03.015",
language = "English",
volume = "58",
pages = "69--76",
journal = "European Journal of Pharmaceutics and Biopharmaceutics",
issn = "0939-6411",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Physical stability and moisture sorption of aqueous chitosan-amylose starch films plasticized with polyols

AU - Cervera, Mirna Fernández

AU - Karjalainen, Milja

AU - Airaksinen, Sari

AU - Rantanen, Jukka

AU - Krogars, Karin

AU - Heinämäki, Jyrki

AU - Colarte, Antonio Iraizoz

AU - Yliruusi, Jouko

N1 - Copyright 2004 Elsevier B.V.

PY - 2004/7

Y1 - 2004/7

N2 - The short-term stability and the water sorption of films prepared from binary mixtures of chitosan and native amylose maize starch (Hylon VII) were evaluated using free films. The aqueous polymer solutions of the free films contained 2% (w/w) film formers, glycerol, or erythritol as a plasticizer, as well as acetic acid (1%) and purified water. Characterization of the present fresh and conditioned film formers and free films was done using X-ray diffraction analysis, determination of moisture sorption isotherms, and near infrared spectroscopy. The results indicated that clear changes in the crystallinity of the films are evident within a 3-month period of storage, and the changes in the solid state are dependent on the plasticizer and storage conditions. When stored at ambient conditions for 3 months, the aqueous chitosan-amylose starch films plasticized with erythritol exhibited a partly crystalline structure. This was as a result of sugar recrystallisation due to the high hydrogen bonding. The respective films plasticized with glycerol and stored at 25 degrees C/60% relative humidity (RH) or at 40 degrees C/75% RH remained flexible and amorphous for at least 3 months. The water sorption of the free films greatly increased as a function of storage time at 75 and 95% RH. The second derivative spectra of starting material and free films were capable of distinguishing the internal water from the free water after storage at different relative humidities. Free water resulted in a separate band at a lower wavelength (1903 nm) in comparison to the structured absorbed water band at 1920 nm, in the case of films the free water resulted in a band around 1900 nm.

AB - The short-term stability and the water sorption of films prepared from binary mixtures of chitosan and native amylose maize starch (Hylon VII) were evaluated using free films. The aqueous polymer solutions of the free films contained 2% (w/w) film formers, glycerol, or erythritol as a plasticizer, as well as acetic acid (1%) and purified water. Characterization of the present fresh and conditioned film formers and free films was done using X-ray diffraction analysis, determination of moisture sorption isotherms, and near infrared spectroscopy. The results indicated that clear changes in the crystallinity of the films are evident within a 3-month period of storage, and the changes in the solid state are dependent on the plasticizer and storage conditions. When stored at ambient conditions for 3 months, the aqueous chitosan-amylose starch films plasticized with erythritol exhibited a partly crystalline structure. This was as a result of sugar recrystallisation due to the high hydrogen bonding. The respective films plasticized with glycerol and stored at 25 degrees C/60% relative humidity (RH) or at 40 degrees C/75% RH remained flexible and amorphous for at least 3 months. The water sorption of the free films greatly increased as a function of storage time at 75 and 95% RH. The second derivative spectra of starting material and free films were capable of distinguishing the internal water from the free water after storage at different relative humidities. Free water resulted in a separate band at a lower wavelength (1903 nm) in comparison to the structured absorbed water band at 1920 nm, in the case of films the free water resulted in a band around 1900 nm.

KW - Amylose

KW - Chitosan

KW - Drug Stability

KW - Humidity

KW - Plasticizers

KW - Polymers

KW - Starch

U2 - 10.1016/j.ejpb.2004.03.015

DO - 10.1016/j.ejpb.2004.03.015

M3 - Journal article

C2 - 15207539

VL - 58

SP - 69

EP - 76

JO - European Journal of Pharmaceutics and Biopharmaceutics

JF - European Journal of Pharmaceutics and Biopharmaceutics

SN - 0939-6411

IS - 1

ER -

ID: 140623243