Forskning ved Københavns Universitet - Københavns Universitet

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Physiological and behavioural stress responses in cynomolgus macaques (Macaca fascicularis) to noise associated with construction work

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • K Westlund
  • A-L Fernström
  • E-M Wergård
  • H Fredlund
  • Hau, Jann
  • M Spångberg
The aim of the present study was to evaluate the behavioural and physiological responses to environmental disturbances (live and recorded dynamite explosions) in laboratory non-human primates in preparation for a future tunnel construction underneath our animal facility. In a pilot study (A) on 20 female Macaca fascicularis, a day of test blasts resulted in an increase in faecal cortisol and immunoreactive cortisol metabolites (CICM), and the animals reacted behaviourally with vertical flight and vocalizations. In a follow-up study (B), we assessed the impact of 10 days of exposure to recorded detonations on the behaviour and CICM in 16 M. fascicularis. In the latter study we introduced a predictive signal, serving as a conditional stimulus, to half of the animals. We found no significant effects of the noise in the Signal group; while the Control groups' CICM values were affected. The behaviour was largely unaffected in the two groups. It was decided not to introduce a research moratorium on biomedical research planned to be conducted during the future tunnel construction, and that a conditional stimulus ('warning signal') will be used.
OriginalsprogEngelsk
TidsskriftLaboratory Animals
Vol/bind46
Udgave nummer1
Sider (fra-til)51-8
Antal sider8
ISSN0023-6772
DOI
StatusUdgivet - jan. 2012

ID: 48008964