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Pituitary mammosomatotroph adenomas develop in old mice transgenic for growth hormone-releasing hormone

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It has been shown that mice transgenic for human growth hormone-releasing hormone (GRH) develop hyperplasia of pituitary somatotrophs and mammosomatotrophs, cells capable of producing both growth hormone and prolactin, by 8 months of age. We now report for the first time that old GRH-transgenic mice, 16 to 24 months of age, develop pituitary mammosomatotroph adenomas. These findings provide conclusive evidence that protracted stimulation of secretory activity can cause proliferation, hyperplasia and adenoma of adenohypophysial cells.

OriginalsprogEngelsk
TidsskriftProceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Vol/bind193
Udgave nummer3
Sider (fra-til)232-5
Antal sider4
ISSN0037-9727
StatusUdgivet - mar. 1990

ID: 132900636