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Plasma volume in acute hypoxia: comparison of a carbon monoxide rebreathing method and dye dilution with Evans' blue

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Standard

Plasma volume in acute hypoxia : comparison of a carbon monoxide rebreathing method and dye dilution with Evans' blue. / Poulsen, T D; Klausen, T; Richalet, J P; Kanstrup, I L; Fogh-Andersen, N; Olsen, Niels Vidiendal.

I: European Journal of Applied Physiology and Occupational Physiology, Bind 77, Nr. 5, 04.1998, s. 457-61.

Publikation: Bidrag til tidsskriftTidsskriftartikel

Harvard

Poulsen, TD, Klausen, T, Richalet, JP, Kanstrup, IL, Fogh-Andersen, N & Olsen, NV 1998, 'Plasma volume in acute hypoxia: comparison of a carbon monoxide rebreathing method and dye dilution with Evans' blue', European Journal of Applied Physiology and Occupational Physiology, bind 77, nr. 5, s. 457-61.

APA

Poulsen, T. D., Klausen, T., Richalet, J. P., Kanstrup, I. L., Fogh-Andersen, N., & Olsen, N. V. (1998). Plasma volume in acute hypoxia: comparison of a carbon monoxide rebreathing method and dye dilution with Evans' blue. European Journal of Applied Physiology and Occupational Physiology, 77(5), 457-61.

Vancouver

Poulsen TD, Klausen T, Richalet JP, Kanstrup IL, Fogh-Andersen N, Olsen NV. Plasma volume in acute hypoxia: comparison of a carbon monoxide rebreathing method and dye dilution with Evans' blue. European Journal of Applied Physiology and Occupational Physiology. 1998 apr;77(5):457-61.

Author

Poulsen, T D ; Klausen, T ; Richalet, J P ; Kanstrup, I L ; Fogh-Andersen, N ; Olsen, Niels Vidiendal. / Plasma volume in acute hypoxia : comparison of a carbon monoxide rebreathing method and dye dilution with Evans' blue. I: European Journal of Applied Physiology and Occupational Physiology. 1998 ; Bind 77, Nr. 5. s. 457-61.

Bibtex

@article{c0dec3be2f27437c93c58f52dca374e8,
title = "Plasma volume in acute hypoxia: comparison of a carbon monoxide rebreathing method and dye dilution with Evans' blue",
abstract = "Exposure to acute hypoxia is associated with changes in body fluid homeostasis and plasma volume (PV). This study compared a dye dilution technique using Evans' blue (PV[Evans']) with a carbon monoxide (CO) rebreathing method (PV[CO]) for measurements of PV in ten normal subjects at sea level and again 24 h after rapid passive ascent to high altitude (4,350 m). Hypobaric hypoxia decreased arterial oxygen saturation to 79 (74-83){\%} (mean with 95{\%} confidence intervals). The PV(Evans') remained unchanged from 3.49 (3.30-3.68) l at sea level to 3.46 (3.24-3.68) l at high altitude. In contrast PV(CO) decreased from 3.39 (3.17-3.61) l at sea level to 3.04 (2.75-3.33) l at high altitude (P <0.05). Compared with sea level, this resulted in an increase of the mean bias between the two methods [from 0.11 (-0.05-0.27) l at sea level to 0.43 (0.26-0.60) l at high altitude] so that the ratio between PV(Evans') and PV(CO) increased from 1.04 (0.99-1.09) at sea level to 1.15 (1.06-1.24) at high altitude (P <0.05). In conclusion, the two methods were not interchangeable as measures of hypoxia-induced changes in PV. The mechanism responsible for the bias remains unknown, but it is suggested that the results may reflect a redistribution of albumin caused by the combined effects in hypoxia of both an increased capillary permeability to albumin and a decrease in PV. As a result, the small perivascular compartment of albumin beyond the endothelium may increase without changes in the overall albumin distribution volume.",
keywords = "Acute Disease, Altitude, Altitude Sickness, Anoxia, Blood Pressure, Capillary Permeability, Carbon Monoxide, Coloring Agents, Dye Dilution Technique, Evans Blue, Heart Rate, Homeostasis, Humans, Hydrogen-Ion Concentration, Male, Oxygen, Plasma Volume, Serum Albumin",
author = "Poulsen, {T D} and T Klausen and Richalet, {J P} and Kanstrup, {I L} and N Fogh-Andersen and Olsen, {Niels Vidiendal}",
year = "1998",
month = "4",
language = "English",
volume = "77",
pages = "457--61",
journal = "European Journal of Applied Physiology and Occupational Physiology",
issn = "0301-5548",
publisher = "Springer Verlag",
number = "5",

}

RIS

TY - JOUR

T1 - Plasma volume in acute hypoxia

T2 - comparison of a carbon monoxide rebreathing method and dye dilution with Evans' blue

AU - Poulsen, T D

AU - Klausen, T

AU - Richalet, J P

AU - Kanstrup, I L

AU - Fogh-Andersen, N

AU - Olsen, Niels Vidiendal

PY - 1998/4

Y1 - 1998/4

N2 - Exposure to acute hypoxia is associated with changes in body fluid homeostasis and plasma volume (PV). This study compared a dye dilution technique using Evans' blue (PV[Evans']) with a carbon monoxide (CO) rebreathing method (PV[CO]) for measurements of PV in ten normal subjects at sea level and again 24 h after rapid passive ascent to high altitude (4,350 m). Hypobaric hypoxia decreased arterial oxygen saturation to 79 (74-83)% (mean with 95% confidence intervals). The PV(Evans') remained unchanged from 3.49 (3.30-3.68) l at sea level to 3.46 (3.24-3.68) l at high altitude. In contrast PV(CO) decreased from 3.39 (3.17-3.61) l at sea level to 3.04 (2.75-3.33) l at high altitude (P <0.05). Compared with sea level, this resulted in an increase of the mean bias between the two methods [from 0.11 (-0.05-0.27) l at sea level to 0.43 (0.26-0.60) l at high altitude] so that the ratio between PV(Evans') and PV(CO) increased from 1.04 (0.99-1.09) at sea level to 1.15 (1.06-1.24) at high altitude (P <0.05). In conclusion, the two methods were not interchangeable as measures of hypoxia-induced changes in PV. The mechanism responsible for the bias remains unknown, but it is suggested that the results may reflect a redistribution of albumin caused by the combined effects in hypoxia of both an increased capillary permeability to albumin and a decrease in PV. As a result, the small perivascular compartment of albumin beyond the endothelium may increase without changes in the overall albumin distribution volume.

AB - Exposure to acute hypoxia is associated with changes in body fluid homeostasis and plasma volume (PV). This study compared a dye dilution technique using Evans' blue (PV[Evans']) with a carbon monoxide (CO) rebreathing method (PV[CO]) for measurements of PV in ten normal subjects at sea level and again 24 h after rapid passive ascent to high altitude (4,350 m). Hypobaric hypoxia decreased arterial oxygen saturation to 79 (74-83)% (mean with 95% confidence intervals). The PV(Evans') remained unchanged from 3.49 (3.30-3.68) l at sea level to 3.46 (3.24-3.68) l at high altitude. In contrast PV(CO) decreased from 3.39 (3.17-3.61) l at sea level to 3.04 (2.75-3.33) l at high altitude (P <0.05). Compared with sea level, this resulted in an increase of the mean bias between the two methods [from 0.11 (-0.05-0.27) l at sea level to 0.43 (0.26-0.60) l at high altitude] so that the ratio between PV(Evans') and PV(CO) increased from 1.04 (0.99-1.09) at sea level to 1.15 (1.06-1.24) at high altitude (P <0.05). In conclusion, the two methods were not interchangeable as measures of hypoxia-induced changes in PV. The mechanism responsible for the bias remains unknown, but it is suggested that the results may reflect a redistribution of albumin caused by the combined effects in hypoxia of both an increased capillary permeability to albumin and a decrease in PV. As a result, the small perivascular compartment of albumin beyond the endothelium may increase without changes in the overall albumin distribution volume.

KW - Acute Disease

KW - Altitude

KW - Altitude Sickness

KW - Anoxia

KW - Blood Pressure

KW - Capillary Permeability

KW - Carbon Monoxide

KW - Coloring Agents

KW - Dye Dilution Technique

KW - Evans Blue

KW - Heart Rate

KW - Homeostasis

KW - Humans

KW - Hydrogen-Ion Concentration

KW - Male

KW - Oxygen

KW - Plasma Volume

KW - Serum Albumin

M3 - Journal article

C2 - 9562298

VL - 77

SP - 457

EP - 461

JO - European Journal of Applied Physiology and Occupational Physiology

JF - European Journal of Applied Physiology and Occupational Physiology

SN - 0301-5548

IS - 5

ER -

ID: 47240367