Forskning ved Københavns Universitet - Københavns Universitet

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PNA-peptidnukleinsyrer. På vej mod genterapeutiske laegemidler

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

The principles of gene therapeutic "antigen" and "antisense" drugs are briefly presented. The target of such drugs is the genetic material of the cell--either the DNA itself, or its messenger molecules, mRNA. By exploiting base-complementary principles, "antigen" and especially "antisense" drugs can easily be designed to target specific genes, the activity of which it is medically advantageous to inhibit. These could be virus- or oncogenes. In particular, the prospects of using peptide nucleic acids (PNA) as gene therapeutic drugs are discussed. PNA is a synthetic structural DNA mimic, which chemically is more closely related to peptides and proteins and which has so far shown very promising chemical and (molecular) biological properties in terms of its development into gene therapeutic drugs as well as diagnostic tools.

OriginalsprogDansk
TidsskriftUgeskrift for Laeger
Vol/bind160
Udgave nummer36
Sider (fra-til)5171-4
Antal sider4
ISSN0041-5782
StatusUdgivet - 31 aug. 1998

    Forskningsområder

  • DNA, DNA, Antisense, Genetic Therapy, Humans, Molecular Structure, Oligonucleotides, Antisense, Peptides, Protein Conformation

ID: 154515497