Forskning ved Københavns Universitet - Københavns Universitet

Forside

Polymer‐supported synthesis of deoxyoligonucleotides using in‐situ prepared deoxynucleoside 2‐cyanoethyl phosphoramidites

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

The easily accessible reagent 2‐cyanoethyl‐bis (diisopropylamino) phosphoramidite is shown to be suitable for the in‐situ, 1H‐tetrazole catalysed, preparation of d‐nucleoside‐3′‐phosphoramidites. The latter compounds could be applied successfully as building blocks in a solid‐phase DNA synthesis using an automated DNA synthesizer.

OriginalsprogEngelsk
TidsskriftRecueil des Travaux Chimiques des Pays‐Bas
Vol/bind105
Udgave nummer1
Sider (fra-til)33-34
Antal sider2
ISSN0165-0513
DOI
StatusUdgivet - 1 jan. 1986

ID: 209550819