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Polymorphisms in the ABCB1 gene and effect on outcome and toxicity in childhood acute lymphoblastic leukemia

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Polymorphisms in the ABCB1 gene and effect on outcome and toxicity in childhood acute lymphoblastic leukemia. / Gregers, J; Gréen, H; Christensen, I J; Dalhoff, K; Schroeder, H; Carlsen, N; Rosthoej, S; Lausen, B; Schmiegelow, K; Peterson, C.

I: Pharmacogenomics Journal, Bind 15, Nr. 4, 08.2015, s. 372-9.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Gregers, J, Gréen, H, Christensen, IJ, Dalhoff, K, Schroeder, H, Carlsen, N, Rosthoej, S, Lausen, B, Schmiegelow, K & Peterson, C 2015, 'Polymorphisms in the ABCB1 gene and effect on outcome and toxicity in childhood acute lymphoblastic leukemia', Pharmacogenomics Journal, bind 15, nr. 4, s. 372-9. https://doi.org/10.1038/tpj.2014.81

APA

Gregers, J., Gréen, H., Christensen, I. J., Dalhoff, K., Schroeder, H., Carlsen, N., ... Peterson, C. (2015). Polymorphisms in the ABCB1 gene and effect on outcome and toxicity in childhood acute lymphoblastic leukemia. Pharmacogenomics Journal, 15(4), 372-9. https://doi.org/10.1038/tpj.2014.81

Vancouver

Gregers J, Gréen H, Christensen IJ, Dalhoff K, Schroeder H, Carlsen N o.a. Polymorphisms in the ABCB1 gene and effect on outcome and toxicity in childhood acute lymphoblastic leukemia. Pharmacogenomics Journal. 2015 aug;15(4):372-9. https://doi.org/10.1038/tpj.2014.81

Author

Gregers, J ; Gréen, H ; Christensen, I J ; Dalhoff, K ; Schroeder, H ; Carlsen, N ; Rosthoej, S ; Lausen, B ; Schmiegelow, K ; Peterson, C. / Polymorphisms in the ABCB1 gene and effect on outcome and toxicity in childhood acute lymphoblastic leukemia. I: Pharmacogenomics Journal. 2015 ; Bind 15, Nr. 4. s. 372-9.

Bibtex

@article{8a57ca27241a4e0db84db0b1be66fe39,
title = "Polymorphisms in the ABCB1 gene and effect on outcome and toxicity in childhood acute lymphoblastic leukemia",
abstract = "The membrane transporter P-glycoprotein, encoded by the ABCB1 gene, influences the pharmacokinetics of anti-cancer drugs. We hypothesized that variants of ABCB1 affect outcome and toxicity in childhood acute lymphoblastic leukemia (ALL). We studied 522 Danish children with ALL, 93{\%} of all those eligible. Risk of relapse was increased 2.9-fold for patients with the 1199GA variant versus 1199GG (P=0.001), and reduced 61{\%} and 40{\%}, respectively, for patients with the 3435CT or 3435TT variants versus 3435CC (overall P=0.02). The degree of bone marrow toxicity during doxorubicin, vincristine and prednisolone induction therapy was more prominent in patients with 3435TT variant versus 3435CT/3435CC (P=0.01/P<0.0001). We observed more liver toxicity after high-dose methotrexate in patients with 3435CC variant versus 3435CT/TT (P=0.03). In conclusion, there is a statistically significant association between ABCB1 polymorphisms, efficacy and toxicity in the treatment of ALL, and ABCB1 1199G>A may be a new possible predictive marker for outcome in childhood ALL.",
keywords = "Acute Disease, Adolescent, Antineoplastic Agents, Bone Marrow Diseases, Child, Child, Preschool, Denmark, Drug-Induced Liver Injury, Genotype, Haplotypes, Humans, Infant, Male, Methotrexate, P-Glycoproteins, Polymorphism, Genetic, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Predictive Value of Tests, Recurrence, Risk Assessment, Treatment Outcome",
author = "J Gregers and H Gr{\'e}en and Christensen, {I J} and K Dalhoff and H Schroeder and N Carlsen and S Rosthoej and B Lausen and K Schmiegelow and C Peterson",
year = "2015",
month = "8",
doi = "10.1038/tpj.2014.81",
language = "English",
volume = "15",
pages = "372--9",
journal = "The Pharmacogenomics Journal",
issn = "1470-269X",
publisher = "nature publishing group",
number = "4",

}

RIS

TY - JOUR

T1 - Polymorphisms in the ABCB1 gene and effect on outcome and toxicity in childhood acute lymphoblastic leukemia

AU - Gregers, J

AU - Gréen, H

AU - Christensen, I J

AU - Dalhoff, K

AU - Schroeder, H

AU - Carlsen, N

AU - Rosthoej, S

AU - Lausen, B

AU - Schmiegelow, K

AU - Peterson, C

PY - 2015/8

Y1 - 2015/8

N2 - The membrane transporter P-glycoprotein, encoded by the ABCB1 gene, influences the pharmacokinetics of anti-cancer drugs. We hypothesized that variants of ABCB1 affect outcome and toxicity in childhood acute lymphoblastic leukemia (ALL). We studied 522 Danish children with ALL, 93% of all those eligible. Risk of relapse was increased 2.9-fold for patients with the 1199GA variant versus 1199GG (P=0.001), and reduced 61% and 40%, respectively, for patients with the 3435CT or 3435TT variants versus 3435CC (overall P=0.02). The degree of bone marrow toxicity during doxorubicin, vincristine and prednisolone induction therapy was more prominent in patients with 3435TT variant versus 3435CT/3435CC (P=0.01/P<0.0001). We observed more liver toxicity after high-dose methotrexate in patients with 3435CC variant versus 3435CT/TT (P=0.03). In conclusion, there is a statistically significant association between ABCB1 polymorphisms, efficacy and toxicity in the treatment of ALL, and ABCB1 1199G>A may be a new possible predictive marker for outcome in childhood ALL.

AB - The membrane transporter P-glycoprotein, encoded by the ABCB1 gene, influences the pharmacokinetics of anti-cancer drugs. We hypothesized that variants of ABCB1 affect outcome and toxicity in childhood acute lymphoblastic leukemia (ALL). We studied 522 Danish children with ALL, 93% of all those eligible. Risk of relapse was increased 2.9-fold for patients with the 1199GA variant versus 1199GG (P=0.001), and reduced 61% and 40%, respectively, for patients with the 3435CT or 3435TT variants versus 3435CC (overall P=0.02). The degree of bone marrow toxicity during doxorubicin, vincristine and prednisolone induction therapy was more prominent in patients with 3435TT variant versus 3435CT/3435CC (P=0.01/P<0.0001). We observed more liver toxicity after high-dose methotrexate in patients with 3435CC variant versus 3435CT/TT (P=0.03). In conclusion, there is a statistically significant association between ABCB1 polymorphisms, efficacy and toxicity in the treatment of ALL, and ABCB1 1199G>A may be a new possible predictive marker for outcome in childhood ALL.

KW - Acute Disease

KW - Adolescent

KW - Antineoplastic Agents

KW - Bone Marrow Diseases

KW - Child

KW - Child, Preschool

KW - Denmark

KW - Drug-Induced Liver Injury

KW - Genotype

KW - Haplotypes

KW - Humans

KW - Infant

KW - Male

KW - Methotrexate

KW - P-Glycoproteins

KW - Polymorphism, Genetic

KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma

KW - Predictive Value of Tests

KW - Recurrence

KW - Risk Assessment

KW - Treatment Outcome

U2 - 10.1038/tpj.2014.81

DO - 10.1038/tpj.2014.81

M3 - Journal article

C2 - 25582575

VL - 15

SP - 372

EP - 379

JO - The Pharmacogenomics Journal

JF - The Pharmacogenomics Journal

SN - 1470-269X

IS - 4

ER -

ID: 160872582