Forskning ved Københavns Universitet - Københavns Universitet

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Prediction of clinical response based on pharmacokinetic/pharmacodynamic models of 5-hydroxytryptamine reuptake inhibitors in mice

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Mads Kreilgaard
  • D G Smith
  • L T Brennum
  • C Sánchez
Bridging the gap between preclinical research and clinical trials is vital for drug development. Predicting clinically relevant steady-state drug concentrations (Css) in serum from preclinical animal models may facilitate this transition. Here we used a pharmacokinetic/pharmacodynamic (PK/PD) modelling approach to evaluate the predictive validity of 5-hydroxytryptamine (5-HT; serotonin) transporter (SERT) occupancy and 5-hydroxytryptophan (5-HTP)-potentiated behavioral syndrome induced by 5-HT reuptake inhibitor (SRI) antidepressants in mice.
OriginalsprogEngelsk
TidsskriftBritish Journal of Pharmacology
Vol/bind155
Udgave nummer2
Sider (fra-til)276-84
Antal sider9
ISSN0007-1188
DOI
StatusUdgivet - sep. 2008

ID: 100994557