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Pregnancy and risk of non-Hodgkin's lymphoma: A prospective study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Pregnancy and risk of non-Hodgkin's lymphoma : A prospective study. / Adami, Hans Olov; Tsaih, Shirng Wern; Lambe, Mats; Hsieh, Chung Cheng; Adami, Johanna; Trichopoulos, Dimitrios; Melbye, Mads; Glimelius, Bengt.

I: International Journal of Cancer, Bind 70, Nr. 2, 1997, s. 155-158.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Adami, HO, Tsaih, SW, Lambe, M, Hsieh, CC, Adami, J, Trichopoulos, D, Melbye, M & Glimelius, B 1997, 'Pregnancy and risk of non-Hodgkin's lymphoma: A prospective study', International Journal of Cancer, bind 70, nr. 2, s. 155-158. https://doi.org/10.1002/(SICI)1097-0215(19970117)70:2<155::AID-IJC3>3.0.CO;2-W

APA

Adami, H. O., Tsaih, S. W., Lambe, M., Hsieh, C. C., Adami, J., Trichopoulos, D., Melbye, M., & Glimelius, B. (1997). Pregnancy and risk of non-Hodgkin's lymphoma: A prospective study. International Journal of Cancer, 70(2), 155-158. https://doi.org/10.1002/(SICI)1097-0215(19970117)70:2<155::AID-IJC3>3.0.CO;2-W

Vancouver

Adami HO, Tsaih SW, Lambe M, Hsieh CC, Adami J, Trichopoulos D o.a. Pregnancy and risk of non-Hodgkin's lymphoma: A prospective study. International Journal of Cancer. 1997;70(2):155-158. https://doi.org/10.1002/(SICI)1097-0215(19970117)70:2<155::AID-IJC3>3.0.CO;2-W

Author

Adami, Hans Olov ; Tsaih, Shirng Wern ; Lambe, Mats ; Hsieh, Chung Cheng ; Adami, Johanna ; Trichopoulos, Dimitrios ; Melbye, Mads ; Glimelius, Bengt. / Pregnancy and risk of non-Hodgkin's lymphoma : A prospective study. I: International Journal of Cancer. 1997 ; Bind 70, Nr. 2. s. 155-158.

Bibtex

@article{441c767bf3f84c3a901814ead5443114,
title = "Pregnancy and risk of non-Hodgkin's lymphoma: A prospective study",
abstract = "The etiology of non-Hodgkin's lymphomas (NHL), including chronic lymphocytic leukemia (CLL), is likely to be related to immune function. In the light of the established immunologic effects of a pregnancy, we decided to examine the risk of NHL and CLL in relationship to full-term pregnancies. Within a nationwide cohort we identified 1,546 women with NHL and 198 women with CLL, all 15 years or older, born 1925-1972. Five age-matched controls were selected for each case patient. Conditional logistic regression was used to estimate the odds ratios after mutual adjustment for number of births and age at first birth. We found a weak, negative association between parity and risk of NHL (p for trend 0.11) and a transient, 10-40% decrease in risk within 5-14 years after the last birth among women with various parity status. The risk of CLL decreased more markedly, and orderly with increasing parity, but the trend was not significant (p = 0.18). Small numbers of cases with CLL prevented more detailed analyses of temporal relationships. Age at first birth appeared unrelated to the risk of both NHL and CLL. We conclude that the immunologic alterations associated with a pregnancy have limited, if any, relevance to the etiology of NHL and CLL; changing reproductive pattern is an unlikely contributor to the marked increase in incidence of NHL seen in many populations.",
author = "Adami, {Hans Olov} and Tsaih, {Shirng Wern} and Mats Lambe and Hsieh, {Chung Cheng} and Johanna Adami and Dimitrios Trichopoulos and Mads Melbye and Bengt Glimelius",
year = "1997",
doi = "10.1002/(SICI)1097-0215(19970117)70:2<155::AID-IJC3>3.0.CO;2-W",
language = "English",
volume = "70",
pages = "155--158",
journal = "International Journal of Cancer. Supplement",
issn = "0898-6924",
publisher = "JohnWiley & Sons, Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Pregnancy and risk of non-Hodgkin's lymphoma

T2 - A prospective study

AU - Adami, Hans Olov

AU - Tsaih, Shirng Wern

AU - Lambe, Mats

AU - Hsieh, Chung Cheng

AU - Adami, Johanna

AU - Trichopoulos, Dimitrios

AU - Melbye, Mads

AU - Glimelius, Bengt

PY - 1997

Y1 - 1997

N2 - The etiology of non-Hodgkin's lymphomas (NHL), including chronic lymphocytic leukemia (CLL), is likely to be related to immune function. In the light of the established immunologic effects of a pregnancy, we decided to examine the risk of NHL and CLL in relationship to full-term pregnancies. Within a nationwide cohort we identified 1,546 women with NHL and 198 women with CLL, all 15 years or older, born 1925-1972. Five age-matched controls were selected for each case patient. Conditional logistic regression was used to estimate the odds ratios after mutual adjustment for number of births and age at first birth. We found a weak, negative association between parity and risk of NHL (p for trend 0.11) and a transient, 10-40% decrease in risk within 5-14 years after the last birth among women with various parity status. The risk of CLL decreased more markedly, and orderly with increasing parity, but the trend was not significant (p = 0.18). Small numbers of cases with CLL prevented more detailed analyses of temporal relationships. Age at first birth appeared unrelated to the risk of both NHL and CLL. We conclude that the immunologic alterations associated with a pregnancy have limited, if any, relevance to the etiology of NHL and CLL; changing reproductive pattern is an unlikely contributor to the marked increase in incidence of NHL seen in many populations.

AB - The etiology of non-Hodgkin's lymphomas (NHL), including chronic lymphocytic leukemia (CLL), is likely to be related to immune function. In the light of the established immunologic effects of a pregnancy, we decided to examine the risk of NHL and CLL in relationship to full-term pregnancies. Within a nationwide cohort we identified 1,546 women with NHL and 198 women with CLL, all 15 years or older, born 1925-1972. Five age-matched controls were selected for each case patient. Conditional logistic regression was used to estimate the odds ratios after mutual adjustment for number of births and age at first birth. We found a weak, negative association between parity and risk of NHL (p for trend 0.11) and a transient, 10-40% decrease in risk within 5-14 years after the last birth among women with various parity status. The risk of CLL decreased more markedly, and orderly with increasing parity, but the trend was not significant (p = 0.18). Small numbers of cases with CLL prevented more detailed analyses of temporal relationships. Age at first birth appeared unrelated to the risk of both NHL and CLL. We conclude that the immunologic alterations associated with a pregnancy have limited, if any, relevance to the etiology of NHL and CLL; changing reproductive pattern is an unlikely contributor to the marked increase in incidence of NHL seen in many populations.

UR - http://www.scopus.com/inward/record.url?scp=0031018194&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1097-0215(19970117)70:2<155::AID-IJC3>3.0.CO;2-W

DO - 10.1002/(SICI)1097-0215(19970117)70:2<155::AID-IJC3>3.0.CO;2-W

M3 - Journal article

C2 - 9009153

AN - SCOPUS:0031018194

VL - 70

SP - 155

EP - 158

JO - International Journal of Cancer. Supplement

JF - International Journal of Cancer. Supplement

SN - 0898-6924

IS - 2

ER -

ID: 259818927