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Preoperative plasma plasminogen activator inhibitor type-1 and serum C-reactive protein levels in patients with colorectal cancer

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Hans Jørgen Nielsen
  • Ib Jarle Christensen
  • Steen Sørensen
  • Flemming Moesgaard
  • Svend Schulze
  • Jens Thorup
  • Peer Wille-Jørgensen
  • Erik Bentzen
  • Lars Banke
  • Dorthe Froberg
  • Finn W. Henriksen
  • Poul Crone
  • Peter Hesselfeldt
  • Bo Hempel-Sparsø
  • Karen Lindorff Larsen
  • Torsten Asmussen
  • Jørgen Heiner
  • Henrik Flyger
  • Per Jess
  • Jørgen Iversen
  • Jørgen La Cour Andersen
  • Bo Vennits
  • Janne H. Hammer
  • Anders Fischer
  • Hanne Galatius
  • Lars Naver
  • Dorthe Teilum
  • Leif Holbraad
  • Ole Iversen
  • Jens Nymark
  • Leif Palm
  • Kirsten C. Rasmussen
  • Jørn Friis
  • Henrik Ovesen
  • Niels Chr Jensen
  • Niels Hoffman
  • Torben Larse
  • Jørgen Packler

Background: Preoperative plasma plasminogen activator inhibitor-1 (PAI-1) is a prognostic variable in patients with colorectal cancer. It has been suggested, however, that plasma PAI-1 is a nonspecific prognostic parameter similar to the acute-phase reactant C-reactive protein (CRP). In the present study we analyzed the association between plasma PAI-1 and serum CRP in patients scheduled for elective resection of colorectal cancer. In addition, the prognostic value of PAI-1 and CRP was studied in this patient cohort. Methods: PAI-1 and CRP were analyzed in citrated plasma and serum, respectively, obtained preoperatively from 594 patients. Patients who required preoperative blood transfusion received SAGM blood, in which soluble PAI-1 is not present. None of the patients received pre- or postoperative adjuvant chemotherapy, and all were followed in the outpatient clinic for at least 5 years or until death. The association of PAI-1 and CRP, respectively, with survival was tested using the median value of PAI-1 and the upper normal limit for CRP. Analyses were performed by inclusion of all patients, and in the subgroup of patients, who underwent curative resection. Results: The median follow-up period was 6.8 (5.4-7.9) years. The median value of plasma PAI-1 was 35.8 ng/ml, and values greater than 94 nmol/L identified patients with increased CRP levels. Comparison of the molecules showed that PAI-1 was weakly correlated with CRP (r = .26; P <.0001). Both molecules showed a Dukes independent distribution. In univariate survival analyses high levels of PAI-1 were found associated with poor prognosis and low levels with good prognosis (P = .02, HR: 1.3). Similarly, high levels of CRP were found associated with poor prognosis and low levels with good prognosis (P <.0001, HR: 1.9). In a multivariate statistical analysis including Dukes classification, gender, age, tumor location, perioperative blood transfusion, PAI-1 and CRP, plasma PAI-1 was a dependent prognostic variable, while serum CRP (P <.0001; HR: 1.4; 95% CI: 1.3-1.5) was found to be a Dukes independent prognostic variable. Similar analyses, excluding patients with Dukes, D disease showed serum CRP to be an independent prognostic variable (P <.0001; HR: 1.3: 95% CI: 1.2-1.5). Conclusions: This study did not show a strong correlation between plasma PAI-1 and serum CRP in patients with colorectal cancer. Serum CRP was found to be a Dukes independent prognostic variable in this patient cohort, and was found to identify a subgroup of curatively resected patients at risk for short survival.

OriginalsprogEngelsk
TidsskriftAnnals of Surgical Oncology
Vol/bind7
Udgave nummer8
Sider (fra-til)617-623
Antal sider7
ISSN1068-9265
DOI
StatusUdgivet - 1 jan. 2000

ID: 203891015