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Preparation of a tritiated ginkgolide

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Preparation of a tritiated ginkgolide. / Strømgaard, Kristian; Suehiro, Makiko; Nakanishi, Koji.

I: Bioorganic & Medicinal Chemistry Letters, Bind 14, Nr. 22, 15.11.2004, s. 5673-5675.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Strømgaard, K, Suehiro, M & Nakanishi, K 2004, 'Preparation of a tritiated ginkgolide', Bioorganic & Medicinal Chemistry Letters, bind 14, nr. 22, s. 5673-5675. https://doi.org/10.1016/j.bmcl.2004.08.042

APA

Strømgaard, K., Suehiro, M., & Nakanishi, K. (2004). Preparation of a tritiated ginkgolide. Bioorganic & Medicinal Chemistry Letters, 14(22), 5673-5675. https://doi.org/10.1016/j.bmcl.2004.08.042

Vancouver

Strømgaard K, Suehiro M, Nakanishi K. Preparation of a tritiated ginkgolide. Bioorganic & Medicinal Chemistry Letters. 2004 nov 15;14(22):5673-5675. https://doi.org/10.1016/j.bmcl.2004.08.042

Author

Strømgaard, Kristian ; Suehiro, Makiko ; Nakanishi, Koji. / Preparation of a tritiated ginkgolide. I: Bioorganic & Medicinal Chemistry Letters. 2004 ; Bind 14, Nr. 22. s. 5673-5675.

Bibtex

@article{1d6a3e301afd4ef695090cf351d50146,
title = "Preparation of a tritiated ginkgolide",
abstract = "Ginkgolide B, a constituent of the tree Ginkgo biloba, was radiolabeled with the beta-emitter tritium ([(3)H]) in two steps from ginkgolide C. First, a triflate precursor was prepared utilizing the selective reactivity of 7-OH in ginkgolide C; the triflate was then reduced with sodium borotritide to yield tritiated ginkgolide B ([(3)H]GB) in good yield and high specific activity. The tritiated ginkgolide will be an important tool for studying neuromodulatory properties of ginkgolides.",
keywords = "Diterpenes, Ginkgo biloba, Ginkgolides, Lactones, Molecular Conformation, Tritium",
author = "Kristian Str{\o}mgaard and Makiko Suehiro and Koji Nakanishi",
year = "2004",
month = "11",
day = "15",
doi = "10.1016/j.bmcl.2004.08.042",
language = "English",
volume = "14",
pages = "5673--5675",
journal = "Bioorganic & Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Pergamon Press",
number = "22",

}

RIS

TY - JOUR

T1 - Preparation of a tritiated ginkgolide

AU - Strømgaard, Kristian

AU - Suehiro, Makiko

AU - Nakanishi, Koji

PY - 2004/11/15

Y1 - 2004/11/15

N2 - Ginkgolide B, a constituent of the tree Ginkgo biloba, was radiolabeled with the beta-emitter tritium ([(3)H]) in two steps from ginkgolide C. First, a triflate precursor was prepared utilizing the selective reactivity of 7-OH in ginkgolide C; the triflate was then reduced with sodium borotritide to yield tritiated ginkgolide B ([(3)H]GB) in good yield and high specific activity. The tritiated ginkgolide will be an important tool for studying neuromodulatory properties of ginkgolides.

AB - Ginkgolide B, a constituent of the tree Ginkgo biloba, was radiolabeled with the beta-emitter tritium ([(3)H]) in two steps from ginkgolide C. First, a triflate precursor was prepared utilizing the selective reactivity of 7-OH in ginkgolide C; the triflate was then reduced with sodium borotritide to yield tritiated ginkgolide B ([(3)H]GB) in good yield and high specific activity. The tritiated ginkgolide will be an important tool for studying neuromodulatory properties of ginkgolides.

KW - Diterpenes

KW - Ginkgo biloba

KW - Ginkgolides

KW - Lactones

KW - Molecular Conformation

KW - Tritium

U2 - 10.1016/j.bmcl.2004.08.042

DO - 10.1016/j.bmcl.2004.08.042

M3 - Journal article

C2 - 15482945

VL - 14

SP - 5673

EP - 5675

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

SN - 0960-894X

IS - 22

ER -

ID: 45824101