Forskning ved Københavns Universitet - Københavns Universitet

Forside

Pre-treatment microbial Prevotella-to-Bacteroides ratio, determines body fat loss success during a 6-month randomized controlled diet intervention

Publikation: Forskning - peer reviewLetter

Mads Fiil Hjorth, Henrik Munch Roager, Thomas Meinert Larsen, Sanne Kellebjerg Poulsen, Tine Rask Licht, Martin I Bahl, Yishai Zohar, Arne Astrup

Based on the abundance of specific bacterial genera, the human gut microbiota can be divided into two relatively stable groups that might play a role in personalized nutrition. We studied these simplified enterotypes as prognostic markers for successful body fat loss on two different diets. A total of 62 participants with increased waist circumference were randomly assigned to receive an ad libitum New Nordic Diet (NND) high in fiber/wholegrain or an Average Danish Diet (ADD) for 26 weeks. Participants were grouped into two discrete enterotypes by their relative abundance of Prevotella spp. divided by Bacteroides spp. (P/B ratio) obtained by quantitative PCR analysis. Modifications of dietary effects of pre-treatment P/B group were examined by linear mixed models. Among individuals with high P/B the NND resulted in a 3.15 kg (95%CI 1.55;4.76, P<0.001) larger body fat loss compared to ADD whereas no differences was observed among individuals with low P/B (0.88 kg [95% CI -0.61;2.37, P=0.25]). Consequently, a 2.27 kg (95%CI 0.09;4.45, P=0.041) difference in responsiveness to the diets were found between the two groups. In summary, subjects with high P/B-ratio appeared more susceptible to lose body fat on diets high in fiber and wholegrain than subjects with a low P/B-ratio.International Journal of Obesity accepted article preview online, 08 September 2017. doi:10.1038/ijo.2017.220.

OriginalsprogEngelsk
BogserieInternational Journal of Obesity
ISSN0307-0565
DOI
StatusE-pub ahead of print - 10 okt. 2017

Bibliografisk note

CURIS 2017 NEXS 270

ID: 183247397