Forskning ved Københavns Universitet - Københavns Universitet

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Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Björn Dahlöf
  • Peter S Sever
  • Neil R Poulter
  • Hans Wedel
  • D Gareth Beevers
  • Mark Caulfield
  • Rory Collins
  • Sverre E Kjeldsen
  • Arni Kristinsson
  • Gordon T McInnes
  • Jesper Mehlsen
  • Markku Nieminen
  • Eoin O'Brien
  • Jan Ostergren
  • ASCOT Investigators
The apparent shortfall in prevention of coronary heart disease (CHD) noted in early hypertension trials has been attributed to disadvantages of the diuretics and beta blockers used. For a given reduction in blood pressure, some suggested that newer agents would confer advantages over diuretics and beta blockers. Our aim, therefore, was to compare the effect on non-fatal myocardial infarction and fatal CHD of combinations of atenolol with a thiazide versus amlodipine with perindopril.
OriginalsprogEngelsk
TidsskriftLancet
Vol/bind366
Udgave nummer9489
Sider (fra-til)895-906
Antal sider12
ISSN0140-6736
DOI
StatusUdgivet - sep. 2005

ID: 34079349