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Prevention of carrageenan-induced pleurisy in mice by anti-CD30 ligand monoclonal antibody

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  • Rosanna Di Paola
  • Roberto Di Marco
  • Emanuela Mazzon
  • Tiziana Genovese
  • Klaus Bendtzen
  • Battesimo Macrì
  • Ferdinando Nicoletti
  • Salvatore Cuzzocrea
CD30 ligand (CD30L) and its receptor CD30 are members of the tumor necrosis factor (TNF) and TNF receptor superfamilies that play a major role in inflammation and immune regulation. To gain insight into the in vivo role of CD30L/CD30 in inflammatory diseases, we have used carrageenan (CAR)-induced pleurisy in mice, a preclinical model of airway inflammation where type 1 proinflammatory cytokines such as interleukin (IL)-1 and TNF-alpha play a key pathogenic role. The data show that prophylactic treatment with anti-CD30L mAb markedly reduces both laboratory and histological signs of CAR-induced pleurisy. These data suggest involvement of CD30-mediated signals in acute immunoinflammatory pathways induced by CAR.
OriginalsprogEngelsk
TidsskriftClinical Immunology
Vol/bind113
Udgave nummer1
Sider (fra-til)64-73
Antal sider10
ISSN1521-6616
DOI
StatusUdgivet - 1 okt. 2004

ID: 34102191