Forskning ved Københavns Universitet - Københavns Universitet


Probing the ligand preferences of the three types of bacterial pantothenate kinase

Publikation: Bidrag til tidsskriftTidsskriftartikel

  • Jinming Guan
  • Leanne Barnard
  • Jeanne Cresson
  • Annabelle Hoegl
  • Justin H Chang
  • Erick Strauss
  • Karine Auclair

Pantothenate kinase (PanK) catalyzes the transformation of pantothenate to 4'-phosphopantothenate, the first committed step in coenzyme A biosynthesis. While numerous pantothenate antimetabolites and PanK inhibitors have been reported for bacterial type I and type II PanKs, only a few weak inhibitors are known for bacterial type III PanK enzymes. Here, a series of pantothenate analogues were synthesized using convenient synthetic methodology. The compounds were exploited as small organic probes to compare the ligand preferences of the three different types of bacterial PanK. Overall, several new inhibitors and substrates were identified for each type of PanK.

TidsskriftBioorganic & Medicinal Chemistry
Udgave nummer22
Sider (fra-til)5896-5902
Antal sider7
StatusUdgivet - 1 dec. 2018
Eksternt udgivetJa

ID: 209575770