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Process for the manufacture of ajoene derivatives

Publikation: Patent

Standard

Process for the manufacture of ajoene derivatives. / Bjarnsholt, Thomas (Opfinder); Hoeiby, Niels (Opfinder); Jensen, Peter Østrup (Opfinder); Phipps, Richard (Opfinder); Shanmugham, Meenakshi, Sundaram (Opfinder); Alhede, Maria (Opfinder); Hultqvist, Louise Dahl (Opfinder); Jakobsen, Tim Holm (Opfinder); Tanner, David (Opfinder); Larsen, Thomas, Ostenfeld (Opfinder); Givskov, Michael (Opfinder).

IPC nr.: C07C 323/ 65 A I. Patentnummer: WO2012076016.

Publikation: Patent

Harvard

Bjarnsholt, T, Hoeiby, N, Jensen, PØ, Phipps, R, Shanmugham, Meenakshi, S, Alhede, M, Hultqvist, LD, Jakobsen, TH, Tanner, D, Larsen, Thomas, O & Givskov, M 2012, Process for the manufacture of ajoene derivatives, Patentnummer WO2012076016, IPC nr. C07C 323/ 65 A I.

APA

Bjarnsholt, T., Hoeiby, N., Jensen, P. Ø., Phipps, R., Shanmugham, Meenakshi, S., Alhede, M., ... Givskov, M. (2012). IPC nr. C07C 323/ 65 A I. Process for the manufacture of ajoene derivatives. (Patentnummer WO2012076016).

Vancouver

Bjarnsholt T, Hoeiby, N, Jensen PØ, Phipps R, Shanmugham, Meenakshi S, Alhede M o.a., Opfindere. Process for the manufacture of ajoene derivatives. C07C 323/ 65 A I. 2012 jun 14.

Author

Bjarnsholt, Thomas (Opfinder) ; Hoeiby, Niels (Opfinder) ; Jensen, Peter Østrup (Opfinder) ; Phipps, Richard (Opfinder) ; Shanmugham, Meenakshi, Sundaram (Opfinder) ; Alhede, Maria (Opfinder) ; Hultqvist, Louise Dahl (Opfinder) ; Jakobsen, Tim Holm (Opfinder) ; Tanner, David (Opfinder) ; Larsen, Thomas, Ostenfeld (Opfinder) ; Givskov, Michael (Opfinder). / Process for the manufacture of ajoene derivatives. IPC nr.: C07C 323/ 65 A I. Patentnummer: WO2012076016.

Bibtex

@misc{58e3ab7e6e49447d8bdbb0a4bfda21ac,
title = "Process for the manufacture of ajoene derivatives",
abstract = "The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C=C- bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.",
author = "Thomas Bjarnsholt and Niels Hoeiby, and Jensen, {Peter {\O}strup} and Richard Phipps and {Shanmugham, Meenakshi}, Sundaram and Maria Alhede and Hultqvist, {Louise Dahl} and Jakobsen, {Tim Holm} and David Tanner and {Larsen, Thomas}, Ostenfeld and Michael Givskov,",
year = "2012",
month = "6",
day = "14",
language = "English",
type = "Patent",
note = "WO2012076016; C07C 323/ 65 A I",

}

RIS

TY - PAT

T1 - Process for the manufacture of ajoene derivatives

AU - Bjarnsholt, Thomas

AU - Hoeiby,, Niels

AU - Jensen, Peter Østrup

AU - Phipps, Richard

AU - Shanmugham, Meenakshi, Sundaram

AU - Alhede, Maria

AU - Hultqvist, Louise Dahl

AU - Jakobsen, Tim Holm

AU - Tanner, David

AU - Larsen, Thomas, Ostenfeld

AU - Givskov,, Michael

PY - 2012/6/14

Y1 - 2012/6/14

N2 - The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C=C- bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.

AB - The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C=C- bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.

M3 - Patent

M1 - WO2012076016

ER -

ID: 180365289