Forskning ved Københavns Universitet - Københavns Universitet

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Proinflammatory effects of exogenously administered IL-10 in experimental autoimmune orchitis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Tetsushi Kaneko
  • Masahiro Itoh
  • Yoichi Nakamura
  • Akira Iimura
  • Shogo Hayashi
  • Kodo Takahashi
  • Franca Stivala
  • Klaus Bendtzen
  • Ferdinando Nicoletti
We studied the effects of exogenously administered recombinant murine interleukin (IL)-10 on the development of experimental autoimmune orchitis (EAO) in C3H/He mice. IL-10 significantly augments histological signs of EAO when administered for 6 consecutive days from days 15 to 20 after primary immunisations with testicular germ cells. These data demonstrate that IL-10, in addition to its well-known antiinflammatory property, also has proinflammatory functions capable of up-regulating testicular immunoinflammatory processes in vivo.
OriginalsprogEngelsk
TidsskriftCytokine
Vol/bind22
Udgave nummer1-2
Sider (fra-til)50-3
Antal sider4
ISSN1043-4666
StatusUdgivet - 1 apr. 2003

ID: 34102015