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Prolonged perceived stress and saliva cortisol in a large cohort of Danish public service employees: cross-sectional and longitudinal associations

Publikation: Forskning - peer reviewTidsskriftartikel

Sigurd Mikkelsen, Julie Lyng Forman, Samuel Fink, Marianne Agergaard Vammen, Jane Frølund Thomsen, Matias Brødsgaard Grynderup, Åse Marie Hansen, Linda Kaerlev, Henrik Albert Kolstad, Reiner Rugulies, Jens Peter Bonde

PURPOSE: It is well known that acute stress can lead to a transient increase in cortisol secretion, but the effects of prolonged stress on cortisol secretion are uncertain. This study examines the cross-sectional and longitudinal associations between prolonged perceived stress and salivary cortisol.

METHODS: In 2007, 4467 Danish public service employees participated in a study of stress and mental health, and 3217 participated in a follow-up in 2009. Perceived stress during the past 4 weeks was assessed by Cohen's four item perceived stress scale. Participants were asked to collect saliva 30 min after awakening and at approximately 20:00 in the evening. The cortisol dependence on perceived stress was examined in regression analyses adjusted for effects of potential confounders. We adjusted for a large variation in saliva sampling times by modelling the time trajectory of cortisol concentrations in the morning and in the evening and examined if they were influenced by perceived stress.

RESULTS: Perceived stress had no statistically significant effects on the level or time trajectory of morning or evening cortisol, neither cross-sectionally nor longitudinally. The 1 month prevalence of frequently perceived stress was low, approximately 2.5%.

CONCLUSION: Our results did not support the hypothesis that prolonged perceived stress is associated with the level or time trajectory of morning or evening salivary cortisol.

OriginalsprogEngelsk
TidsskriftInternational Archives of Occupational and Environmental Health
Vol/bind90
Tidsskriftsnummer8
Sider (fra-til)835–848
Antal sider14
ISSN0340-0131
DOI
StatusUdgivet - nov. 2017

ID: 183246706