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Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard anti-proliferative chemotherapy is relatively ineffective against slowly proliferating androgen-independent prostate cancer cells within metastatic sites. In contrast, the lipophilic cytotoxin thapsigargin, which causes apoptosis by disrupting intracellular free Ca2+ levels, is effective against both proliferative and quiescent (i.e., G0-arrested) cells. However, thapsigargin's mechanism of action indicates that it is unlikely to be selective for cancer cells or prostate cells.
OriginalsprogEngelsk
TidsskriftNational Cancer Institute. Journal (Online)
Vol/bind95
Udgave nummer13
Sider (fra-til)990-1000
Antal sider11
ISSN1460-2105
StatusUdgivet - 2 jul. 2003

ID: 44569411