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Pseudoxylallemycins A-F, cyclic tetrapeptides with rare allenyl modifications isolated from Pseudoxylaria sp. X802: a competitor of fungus-growing termite cultivars

Publikation: Bidrag til tidsskriftLetterForskningfagfællebedømt

  • Huijuan Guo
  • Nina B. Kreuzenbeck
  • Saria Otani
  • Maria Garcia-Altares
  • Hans-Martin Dahse
  • Christiane Weigel
  • Duur K. Aanen
  • Christian Hertweck
  • Poulsen, Michael
  • Christine Beemelmanns

Based on fungus-fungus pairing assays and HRMS-based dereplication strategy, six new cyclic tetrapeptides, pseudoxylallemycins A-F (1-6), were isolated from the termite-associated fungus Pseudoxylaria sp. X802. Structures were characterized using NMR spectroscopy, HRMS, and Marfey's reaction. Pseudoxylallemycins B-D (2-4) possess a rare and chemically accessible allene moiety amenable for synthetic modifications, and derivatives A-D showed antimicrobial activity against Gram-negative human-pathogenic Pseudomonas aeruginosa and antiproliferative activity against human umbilical vein endothelial cells and K-562 cell lines.

OriginalsprogEngelsk
TidsskriftOrganic Letters
Vol/bind18
Udgave nummer14
Sider (fra-til)3338-3341
Antal sider4
ISSN1523-7060
DOI
StatusUdgivet - 2016

ID: 169945955