Forskning ved Københavns Universitet - Københavns Universitet


Quantitative characteristics of spike-wave paroxysms in genetic generalized epilepsy

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Objective: To characterize generalized spike-wave paroxysms (GSW) in children with generalized genetic epilepsy (GGE). Methods: We annotated 15–19 channel scalp EEGs from a retrospective cohort from patients with a variety of GGE syndromes. Connectivity, entropy, frequency, power, spike-amplitudes were compared with a normal baseline activity and analyzed for the effect of age and sex. Cluster analysis was used to group spike-topographies between patients. Results: In total, 864 GSWs from 100 patients aged 2–18 were analyzed. Age had a significant effect on peak frequency, entropy and connectivity. Female sex was associated with significantly higher probability of positive responsiveness to photic stimulation (OR 4.28, CI [1.65, 11.73], p = 0.0036). Entropy decreases significantly during GSW (D = −0.29, CI [−0.31, −0.27], p ≪ 0.0001) and connectivity significantly increases (D = 0.39, CI [0.36, 0.40], p ≪ 0.0001). Within patient spike-voltage maps exhibit remarkable consistency between spikes. Spike-topographies cluster together to predict age, connectivity and entropy. Conclusions: A quantitative characterization is possible and reveals significant relationships between age, sex and spike characteristics and multidimensional EEG features. Significance: Quantitative GSW characterization can capture aspects from traditional qualitative GSW analysis while being unaffected by intra- and interrater variation and this may be useful for multidimensional predictors of patient outcomes in GGE in the future.

TidsskriftClinical Neurophysiology
Udgave nummer6
Sider (fra-til)1230-1240
StatusUdgivet - jun. 2020

ID: 242410964