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Quisqualate, kainate and NMDA can initiate spreading depression in the turtle cerebellum

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Standard

Quisqualate, kainate and NMDA can initiate spreading depression in the turtle cerebellum. / Lauritzen, Martin; Rice, Margaret E.; Okada, Yoshio; Nicholson, Charles.

I: Brain Research, Bind 475, Nr. 2, 20.12.1988, s. 317-327.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Lauritzen, M, Rice, ME, Okada, Y & Nicholson, C 1988, 'Quisqualate, kainate and NMDA can initiate spreading depression in the turtle cerebellum', Brain Research, bind 475, nr. 2, s. 317-327. https://doi.org/10.1016/0006-8993(88)90620-8

APA

Lauritzen, M., Rice, M. E., Okada, Y., & Nicholson, C. (1988). Quisqualate, kainate and NMDA can initiate spreading depression in the turtle cerebellum. Brain Research, 475(2), 317-327. https://doi.org/10.1016/0006-8993(88)90620-8

Vancouver

Lauritzen M, Rice ME, Okada Y, Nicholson C. Quisqualate, kainate and NMDA can initiate spreading depression in the turtle cerebellum. Brain Research. 1988 dec 20;475(2):317-327. https://doi.org/10.1016/0006-8993(88)90620-8

Author

Lauritzen, Martin ; Rice, Margaret E. ; Okada, Yoshio ; Nicholson, Charles. / Quisqualate, kainate and NMDA can initiate spreading depression in the turtle cerebellum. I: Brain Research. 1988 ; Bind 475, Nr. 2. s. 317-327.

Bibtex

@article{609dddf4729b43b4b6ea0c8d0e381cfd,
title = "Quisqualate, kainate and NMDA can initiate spreading depression in the turtle cerebellum",
abstract = "This study evaluated the role of excitatory amino acid (EAA) receptor activation in spreading depression (SD), using the in vitro turtle cerebellum as a model system. SD was triggered by electrical stimulation or by elevated K+ after the cerebellum had been conditioned for at least 30 min with physiological saline in which most of the chloride had been replaced by propionate. SD was recognized as a transient (1-3 min) negative shift of extracellular potential accompanied by depression of evoked potentials (15-30 min) and an increase of extracellular K+ up to 60 mM, which spread across the cerebellum at rates of 1-7 mm/min. SD usually commenced in the granular layer, which apparently contains the 3 major EAA receptor subtypes, quisqualate, kainate and N-methyl-d-aspartate (NMDA), then subsequently spread to the molecular layer, which is largely free of NMDA receptors. Glutamate, aspartate, NMDA, kainate and quisqualate all triggered SD. Kynurenic acid and 2-aminophosphonovaleric acid (APV) inhibited SD under certain conditions further suggesting involvement of EAA receptors. The initiation of SD was blocked by high Mg2+ and facilitated in low extracellular Mg2+, which also eliminated the delay in molecular layer SD onset. Our data suggest that no one EAA receptor subtype is singly responsible for SD.",
keywords = "Aspartate, Glutamate, Ion-selective microelectrode, Kainate, N-methyl-d-aspartate, Quisqualate, Spreading depression, Turtle cerebellum",
author = "Martin Lauritzen and Rice, {Margaret E.} and Yoshio Okada and Charles Nicholson",
year = "1988",
month = dec,
day = "20",
doi = "10.1016/0006-8993(88)90620-8",
language = "English",
volume = "475",
pages = "317--327",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Quisqualate, kainate and NMDA can initiate spreading depression in the turtle cerebellum

AU - Lauritzen, Martin

AU - Rice, Margaret E.

AU - Okada, Yoshio

AU - Nicholson, Charles

PY - 1988/12/20

Y1 - 1988/12/20

N2 - This study evaluated the role of excitatory amino acid (EAA) receptor activation in spreading depression (SD), using the in vitro turtle cerebellum as a model system. SD was triggered by electrical stimulation or by elevated K+ after the cerebellum had been conditioned for at least 30 min with physiological saline in which most of the chloride had been replaced by propionate. SD was recognized as a transient (1-3 min) negative shift of extracellular potential accompanied by depression of evoked potentials (15-30 min) and an increase of extracellular K+ up to 60 mM, which spread across the cerebellum at rates of 1-7 mm/min. SD usually commenced in the granular layer, which apparently contains the 3 major EAA receptor subtypes, quisqualate, kainate and N-methyl-d-aspartate (NMDA), then subsequently spread to the molecular layer, which is largely free of NMDA receptors. Glutamate, aspartate, NMDA, kainate and quisqualate all triggered SD. Kynurenic acid and 2-aminophosphonovaleric acid (APV) inhibited SD under certain conditions further suggesting involvement of EAA receptors. The initiation of SD was blocked by high Mg2+ and facilitated in low extracellular Mg2+, which also eliminated the delay in molecular layer SD onset. Our data suggest that no one EAA receptor subtype is singly responsible for SD.

AB - This study evaluated the role of excitatory amino acid (EAA) receptor activation in spreading depression (SD), using the in vitro turtle cerebellum as a model system. SD was triggered by electrical stimulation or by elevated K+ after the cerebellum had been conditioned for at least 30 min with physiological saline in which most of the chloride had been replaced by propionate. SD was recognized as a transient (1-3 min) negative shift of extracellular potential accompanied by depression of evoked potentials (15-30 min) and an increase of extracellular K+ up to 60 mM, which spread across the cerebellum at rates of 1-7 mm/min. SD usually commenced in the granular layer, which apparently contains the 3 major EAA receptor subtypes, quisqualate, kainate and N-methyl-d-aspartate (NMDA), then subsequently spread to the molecular layer, which is largely free of NMDA receptors. Glutamate, aspartate, NMDA, kainate and quisqualate all triggered SD. Kynurenic acid and 2-aminophosphonovaleric acid (APV) inhibited SD under certain conditions further suggesting involvement of EAA receptors. The initiation of SD was blocked by high Mg2+ and facilitated in low extracellular Mg2+, which also eliminated the delay in molecular layer SD onset. Our data suggest that no one EAA receptor subtype is singly responsible for SD.

KW - Aspartate

KW - Glutamate

KW - Ion-selective microelectrode

KW - Kainate

KW - N-methyl-d-aspartate

KW - Quisqualate

KW - Spreading depression

KW - Turtle cerebellum

UR - http://www.scopus.com/inward/record.url?scp=0024206707&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(88)90620-8

DO - 10.1016/0006-8993(88)90620-8

M3 - Journal article

C2 - 2905624

AN - SCOPUS:0024206707

VL - 475

SP - 317

EP - 327

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 2

ER -

ID: 201456673